Fluperlapin

Fluperlapin
(IUPAC) ime
	3-fluoro-6-(4-metilpiperazin-1-il)-11H-dibenzo[b,e]azepin
Klinički podaci
Identifikatori
CAS broj	67121-76-0
ATC kod	nije dodeljen
PubChem	49381
ChemSpider	44882
UNII	EWG253M961
ChEMBL	CHEMBL63756
Hemijski podaci
Formula	C19H20FN3
Mol. masa	309,381 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C19H20FN3/c1-22-8-10-23(11-9-22)19-17-5-3-2-4-14(17)12-15-6-7-16(20)13-18(15)21-19/h2-7,13H,8-12H2,1H3 ; Key: OBWGMKKHCLHVIE-UHFFFAOYSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

Fluperlapin (NB 106-689, fluoroperlapin) je triciklični atipični antipsihotik sa dodatnim antidepresivnim i sedativnim dejstvom. On je sintetisan 1979. Studiran je na životinjama i ljudima od 1984.^[5] Mada je pokazao efikasnost u tretmanu mnoštva oboljenja, uključujući šizofreniju,^[6]^[7]^[8]^[9] psihozu usled Parkinsonove bolest,^[10] depresiju, i distoniju,^[11] on nije plasiran na tržište.^[5]

Reference[uredi - уреди | uredi izvor]

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. http://www.sciencedirect.com/science/article/pii/S1359644610007737. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. http://www.jcheminf.com/content/2/1/3. edit
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ ^5,0 ^5,1 Ganellin, C. R.; Triggle, D. J.; Macdonald, F. (1997). Dictionary of pharmacological agents. CRC Press. str. 916. ISBN 978-0-412-46630-4. http://books.google.com/books?id=DeX7jgInYFMC&pg=PA916. Pristupljeno 15. 9. 2011..
↑ Fischer-Cornelssen, K. A. (1984). "Fluperlapine in 104 schizophrenic patients. Open multicenter trial". Arzneimittel-Forschung 34 (1A): 125–130. PMID 6145428.
↑ Woggon, B.; Angst, J.; Bartels, M.; Heinrich, K.; Hippius, H.; Koukkou, M.; Krebs, E.; Küfferle, B. i dr.. (1984). "Antipsychotic efficacy of fluperlapine. An open multicenter trial". Neuropsychobiology 11 (2): 116–120. PMID 6148712.
↑ Dieterle, D.; Eben, E.; Einhäupl, K.; Hippius, H.; Klein, H.; Rüther, E.; Schmauß, M. (2008). "The Effect of Fluperlapine in Acute Psychotic Patients". Pharmacopsychiatry 17 (2): 57–60. DOI:10.1055/s-2007-1017408. PMID 6728910.
↑ Woggon, B.; Heinrich, K.; Küfferle, B.; Müller-Oerlinghausen, B.; Pöldinger, W.; Rüther, E.; Schied, H. W. (1984). "Results of a multicenter AMDP study with fluperlapine in schizophrenic patients". Arzneimittel-Forschung 34 (1A): 122–124. PMID 6145427.
↑ Scholz, E.; Dichgans, J. (1985). "Treatment of drug-induced exogenous psychosis in parkinsonism with clozapine and fluperlapine". European archives of psychiatry and neurological sciences 235 (1): 60–64. PMID 2864254.
↑ Pakkenberg, H.; Pedersen, B. (1985). "Medical treatment of dystonia". Psychopharmacology. Supplementum 2: 111–117. ISSN 0179-8456. OCLC 10642795. PMID 2860654.

Literatura[uredi - уреди | uredi izvor]

Ganellin, C. R.; Triggle, D. J.; Macdonald, F. (1997). Dictionary of pharmacological agents. CRC Press. str. 916. ISBN 978-0-412-46630-4. http://books.google.com/books?id=DeX7jgInYFMC&pg=PA916. Pristupljeno 15. 9. 2011..

Vidi još[uredi - уреди | uredi izvor]

Klozapin

Spoljašnje veze[uredi - уреди | uredi izvor]

	Portal Medicina
	Portal Hemija

Šablon:Navbox

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. http://www.sciencedirect.com/science/article/pii/S1359644610007737. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. http://www.jcheminf.com/content/2/1/3. edit

[4] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[Ganellin-5] 5,0 ^5,1 Ganellin, C. R.; Triggle, D. J.; Macdonald, F. (1997). Dictionary of pharmacological agents. CRC Press. str. 916. ISBN 978-0-412-46630-4. http://books.google.com/books?id=DeX7jgInYFMC&pg=PA916. Pristupljeno 15. 9. 2011..

[pmid6145428-6] Fischer-Cornelssen, K. A. (1984). "Fluperlapine in 104 schizophrenic patients. Open multicenter trial". Arzneimittel-Forschung 34 (1A): 125–130. PMID 6145428.

[pmid6148712-7] Woggon, B.; Angst, J.; Bartels, M.; Heinrich, K.; Hippius, H.; Koukkou, M.; Krebs, E.; Küfferle, B. i dr.. (1984). "Antipsychotic efficacy of fluperlapine. An open multicenter trial". Neuropsychobiology 11 (2): 116–120. PMID 6148712.

[pmid6728910-8] Dieterle, D.; Eben, E.; Einhäupl, K.; Hippius, H.; Klein, H.; Rüther, E.; Schmauß, M. (2008). "The Effect of Fluperlapine in Acute Psychotic Patients". Pharmacopsychiatry 17 (2): 57–60. DOI:10.1055/s-2007-1017408. PMID 6728910.

[pmid6145427-9] Woggon, B.; Heinrich, K.; Küfferle, B.; Müller-Oerlinghausen, B.; Pöldinger, W.; Rüther, E.; Schied, H. W. (1984). "Results of a multicenter AMDP study with fluperlapine in schizophrenic patients". Arzneimittel-Forschung 34 (1A): 122–124. PMID 6145427.

[pmid2864254-10] Scholz, E.; Dichgans, J. (1985). "Treatment of drug-induced exogenous psychosis in parkinsonism with clozapine and fluperlapine". European archives of psychiatry and neurological sciences 235 (1): 60–64. PMID 2864254.

[pmid2860654-11] Pakkenberg, H.; Pedersen, B. (1985). "Medical treatment of dystonia". Psychopharmacology. Supplementum 2: 111–117. ISSN 0179-8456. OCLC 10642795. PMID 2860654.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

Fluperlapin

Sadržaj/Садржај

Reference[uredi - уреди | uredi izvor]

Literatura[uredi - уреди | uredi izvor]

Vidi još[uredi - уреди | uredi izvor]

Spoljašnje veze[uredi - уреди | uredi izvor]

Navigacijski meni

Traži-Тражи