Ajmalicin

Iz Wikipedije, slobodne enciklopedije
Ajmalicin
(IUPAC) ime
metil estar (19α)-16,17-didehidro- 19-metiloksajohimban- 16-karboksilne kiseline
Klinički podaci
Identifikatori
CAS broj 483-04-5
ATC kod nije dodeljen
PubChem[1][2] 251561
ChemSpider[3] 390541
ChEMBL[4] CHEMBL123325 YesY
Hemijski podaci
Formula C21H24N2O3 
Mol. masa 352,43 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća  ?
Pravni status Prescription only
Način primene Oralno

Ajmalicin (δ-johimbin, raubazin) je antihipertenziv koji se koristi kao tretman za visoki krvni pritisak.[5] On je bio u prodaji pod raznim imenima, neka od kojih su: Card-Lamuran, Circolene, Cristanyl, Duxil, Duxor, Hydroxysarpon, Iskedyl, Isosarpan, Isquebral, Lamuran, Melanex, Saltucin Co, Salvalion, i Sarpan.[5] On je isto tako alkaloid koji je prirodno javlja u raznim biljkama kao što su Rauwolfia spp., Catharanthus roseus, i Mitragyna speciosa.[5][6][7]

Ajmalicin je strukturno srodan sa johimbinom, rauvolscinom, i drugim johimbanskim derivatima. Poput korinantina, on deluje kao antagonist α1-adrenergičkog receptora. On je znatno manje aktivan na α2-adrenergičkim receptorima, iz čega proizilazi njegovo hipotenzivno dejstvo.[5][8]

Reference[uredi - уреди | uredi izvor]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. PMID 20331846. doi:10.1186/1758-2946-2-3.  edit
  4. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100–7. PMID 21948594. doi:10.1093/nar/gkr777.  edit
  5. 5,0 5,1 5,2 5,3 Wink, Michael; Roberts, M. W. (1998). Alkaloids: biochemistry, ecology, and medicinal applications. New York: Plenum Press. ISBN 0-306-45465-3. http://books.google.com/books?id=bMCzyrAtrvYC&lpg=PA450&dq=ajmalicine&as_brr=3&pg=PA451#v=onepage&q=&f=false. 
  6. Kurz WG, Chatson KB, Constabel F et al. (May 1981). "Alkaloid Production in Catharanthus roseus Cell Cultures VIII1". Planta Medica 42 (5): 22–31. PMID 17401876. doi:10.1055/s-2007-971541. 
  7. León F, Habib E, Adkins JE, Furr EB, McCurdy CR, Cutler SJ (July 2009). "Phytochemical characterization of the leaves of Mitragyna speciosa grown in U.S.A". Natural Product Communications 4 (7): 907–10. PMID 19731590. 
  8. Roquebert J, Demichel P (October 1984). "Inhibition of the alpha 1 and alpha 2-adrenoceptor-mediated pressor response in pithed rats by raubasine, tetrahydroalstonine and akuammigine". European Journal of Pharmacology 106 (1): 203–5. PMID 6099269. doi:10.1016/0014-2999(84)90698-8. 

Vidi još[uredi - уреди | uredi izvor]