Ajmalicin

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Ajmalicin
(IUPAC) ime
metil estar (19α)-16,17-didehidro- 19-metiloksajohimban- 16-karboksilne kiseline
Klinički podaci
Identifikatori
CAS broj 483-04-5
ATC kod nije dodeljen
PubChem[1][2] 251561
ChemSpider[3] 390541
ChEMBL[4] CHEMBL123325 DaY
Hemijski podaci
Formula C21H24N2O3 
Mol. masa 352,43 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća ?
Pravni status Prescription only
Način primene Oralno

Ajmalicin (δ-johimbin, raubazin) je antihipertenziv koji se koristi kao tretman za visoki krvni pritisak.[5] On je bio u prodaji pod raznim imenima, neka od kojih su: Card-Lamuran, Circolene, Cristanyl, Duxil, Duxor, Hydroxysarpon, Iskedyl, Isosarpan, Isquebral, Lamuran, Melanex, Saltucin Co, Salvalion, i Sarpan.[5] On je isto tako alkaloid koji je prirodno javlja u raznim biljkama kao što su Rauwolfia spp., Catharanthus roseus, i Mitragyna speciosa.[5][6][7]

Ajmalicin je strukturno srodan sa johimbinom, rauvolscinom, i drugim johimbanskim derivatima. Poput korinantina, on deluje kao antagonist α1-adrenergičkog receptora. On je znatno manje aktivan na α2-adrenergičkim receptorima, iz čega proizilazi njegovo hipotenzivno dejstvo.[5][8]

Reference[uredi | uredi kod]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.  edit
  4. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.  edit
  5. 5,0 5,1 5,2 5,3 Wink, Michael; Roberts, M. W. (1998). Alkaloids: biochemistry, ecology, and medicinal applications. New York: Plenum Press. ISBN 0-306-45465-3. 
  6. Kurz WG, Chatson KB, Constabel F, et al. (May 1981). „Alkaloid Production in Catharanthus roseus Cell Cultures VIII1”. Planta Medica 42 (5): 22–31. DOI:10.1055/s-2007-971541. PMID 17401876. 
  7. León F, Habib E, Adkins JE, Furr EB, McCurdy CR, Cutler SJ (July 2009). „Phytochemical characterization of the leaves of Mitragyna speciosa grown in U.S.A”. Natural Product Communications 4 (7): 907–10. PMID 19731590. 
  8. Roquebert J, Demichel P (October 1984). „Inhibition of the alpha 1 and alpha 2-adrenoceptor-mediated pressor response in pithed rats by raubasine, tetrahydroalstonine and akuammigine”. European Journal of Pharmacology 106 (1): 203–5. DOI:10.1016/0014-2999(84)90698-8. PMID 6099269. 

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