5-Karboksamidotriptamin

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(Preusmjereno sa 5-karboksamidotriptamin)
5-Karboksamidotriptamin
(IUPAC) ime
3-(2-aminoethyl)-1H-indole-5-carboxamide
Klinički podaci
Identifikatori
CAS broj 74885-09-9
ATC kod nije dodeljen
PubChem[1][2] 1809
ChemSpider[3] 1743
ChEMBL[4] CHEMBL18840 YesY
Hemijski podaci
Formula C11H13N3O 
Mol. masa 203.240 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća  ?
Pravni status

5-Karboksamidotriptamin (5-CT) je triptaminski derivat koji je blisko srodan sa neurotransmiterom serotoninom.

5-CT deluje kao neselektivni pun agonist visokog afiniteta na 5-HT1A, 5-HT1B, 5-HT1D, 5-HT5A, i 5-HT7 receptore, kao i na 5-HT2, 5-HT3, 5-HT6 receptore sa nižim afinitetom.[5][6][7] On ima neznatan afinitet za 5-HT1E i 5-HT1F receptore.[8] 5-CT se najjače vezuje za 5-HT1A receptor i nekad se smatralo da je selektivan za njega.[9][10]

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Literatura[uredi - уреди | uredi izvor]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. PMID 20331846. doi:10.1186/1758-2946-2-3.  edit
  4. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100–7. PMID 21948594. doi:10.1093/nar/gkr777.  edit
  5. Yamada J, Sugimoto Y, Noma T, Yoshikawa T. (1998). "Effects of the non-selective 5-HT receptor agonist, 5-carboxamidotryptamine, on plasma glucose levels in rats.". Eur J Pharmacol. 359 (1): 81–86. PMID 9831297. doi:10.1016/S0014-2999(98)00617-7. 
  6. Wright, CE; Angus, JA (1989). "5-carboxamidotryptamine elicits 5-HT2 and 5-HT3 receptor-mediated cardiovascular responses in the conscious rabbit: evidence for 5-HT release from platelets.". Journal of cardiovascular pharmacology 13 (4): 557–64. PMID 2470992. 
  7. Glennon RA, Dukat M, Westkaemper RB (01. 01. 2000.). "Serotonin Receptor Subtypes and Ligands". American College of Neurophyscopharmacology. http://www.acnp.org/g4/GN401000039/Ch039.html. pristupljeno 11. 04. 2008.. 
  8. Stanton JA, Middlemiss DN, Beer MS. (1996). "Autoradiographic localization of 5-CT-insensitive 5-HT1-like recognition sites in guinea pig and rat brain.". Neuropharmacology. 35 (2): 223–229. PMID 8734492. doi:10.1016/0028-3908(95)00178-6. 
  9. Thomas, DR; Middlemiss, DN; Taylor, SG; Nelson, P; Brown, AM (1999). "5-CT stimulation of adenylyl cyclase activity in guinea-pig hippocampus: evidence for involvement of 5-HT7 and 5-HT1A receptors.". British journal of pharmacology 128 (1): 158–64. PMC 1571602. PMID 10498847. doi:10.1038/sj.bjp.0702759. 
  10. Saxena, PR; Lawang, A (1985). "A comparison of cardiovascular and smooth muscle effects of 5-hydroxytryptamine and 5-carboxamidotryptamine, a selective agonist of 5-HT1 receptors.". Archives internationales de pharmacodynamie et de therapie 277 (2): 235–52. PMID 2933009.