5-Karboksamidotriptamin

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5-Karboksamidotriptamin
(IUPAC) ime
3-(2-aminoethyl)-1H-indole-5-carboxamide
Klinički podaci
Identifikatori
CAS broj 74885-09-9
ATC kod nije dodeljen
PubChem[1][2] 1809
ChemSpider[3] 1743
ChEMBL[4] CHEMBL18840 DaY
Hemijski podaci
Formula C11H13N3O 
Mol. masa 203.240 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća ?
Pravni status

5-Karboksamidotriptamin (5-CT) je triptaminski derivat koji je blisko srodan sa neurotransmiterom serotoninom.

5-CT deluje kao neselektivni pun agonist visokog afiniteta na 5-HT1A, 5-HT1B, 5-HT1D, 5-HT5A, i 5-HT7 receptore, kao i na 5-HT2, 5-HT3, 5-HT6 receptore sa nižim afinitetom.[5][6][7] On ima neznatan afinitet za 5-HT1E i 5-HT1F receptore.[8] 5-CT se najjače vezuje za 5-HT1A receptor i nekad se smatralo da je selektivan za njega.[9][10]

Vidi još[uredi | uredi kod]

Literatura[uredi | uredi kod]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.  edit
  4. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.  edit
  5. Yamada J, Sugimoto Y, Noma T, Yoshikawa T. (1998). „Effects of the non-selective 5-HT receptor agonist, 5-carboxamidotryptamine, on plasma glucose levels in rats.”. Eur J Pharmacol. 359 (1): 81–86. DOI:10.1016/S0014-2999(98)00617-7. PMID 9831297. 
  6. Wright, CE; Angus, JA (1989). „5-carboxamidotryptamine elicits 5-HT2 and 5-HT3 receptor-mediated cardiovascular responses in the conscious rabbit: evidence for 5-HT release from platelets.”. Journal of cardiovascular pharmacology 13 (4): 557–64. PMID 2470992. 
  7. Glennon RA, Dukat M, Westkaemper RB (01. 01. 2000.). „Serotonin Receptor Subtypes and Ligands”. American College of Neurophyscopharmacology. Pristupljeno 11. 04. 2008. 
  8. Stanton JA, Middlemiss DN, Beer MS. (1996). „Autoradiographic localization of 5-CT-insensitive 5-HT1-like recognition sites in guinea pig and rat brain.”. Neuropharmacology. 35 (2): 223–229. DOI:10.1016/0028-3908(95)00178-6. PMID 8734492. 
  9. Thomas, DR; Middlemiss, DN; Taylor, SG; Nelson, P; Brown, AM (1999). „5-CT stimulation of adenylyl cyclase activity in guinea-pig hippocampus: evidence for involvement of 5-HT7 and 5-HT1A receptors.”. British journal of pharmacology 128 (1): 158–64. DOI:10.1038/sj.bjp.0702759. PMC 1571602. PMID 10498847. 
  10. Saxena, PR; Lawang, A (1985). „A comparison of cardiovascular and smooth muscle effects of 5-hydroxytryptamine and 5-carboxamidotryptamine, a selective agonist of 5-HT1 receptors.”. Archives internationales de pharmacodynamie et de therapie 277 (2): 235–52. PMID 2933009.