Ro04-6790

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Ro04-6790
(IUPAC) ime
4-amino-N-[2,6-bis(metilamino)-4-pirimidinil]-benzensulfonamid
Klinički podaci
Identifikatori
CAS broj 202466-68-0
ATC kod nije dodeljen
PubChem[1][2] 5312145
Hemijski podaci
Formula C12H16N6O2S 
Mol. masa 308,359 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća  ?
Pravni status

Ro04-6790 je lek koji se koristi u naučnim istraživanjima. On deluje kao potentan i selektivan receptorski antagonist za 5-HT6 serotoninski receptor, sa malim ili odsustvom afiniteta za druge receptore. Poput drugih lekova ove klase,[3] Ro04-6790 ima nootropne efekte na životinjama,[4] i redukuje amneziju proizvedenu lekovima koji ugrožavaju memoriju, kao što je dizocilpin[5] i skopolamin.[6]

Reference[uredi - уреди | uredi izvor]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Fone KC. An update on the role of the 5-hydroxytryptamine6 receptor in cognitive function. Neuropharmacology. 2008 Nov;55(6):1015-22. DOI:10.1016/j.neuropharm.2008.06.061 PMID 18655798
  4. King MV, Spicer CH, Sleight AJ, Marsden CA, Fone KC. Impact of regional 5-HT depletion on the cognitive enhancing effects of a typical 5-ht(6) receptor antagonist, Ro 04-6790, in the Novel Object Discrimination task. Psychopharmacology (Berlin). 2008 Oct 7. PMID 18839151
  5. Pitsikas N, Zisopoulou S, Pappas I, Sakellaridis N. The selective 5-HT(6) receptor antagonist Ro 04-6790 attenuates psychotomimetic effects of the NMDA receptor antagonist MK-801. Behavioural Brain Research. 2008 Apr 9;188(2):304-9. PMID 18164078
  6. Woolley ML, Marsden CA, Sleight AJ, Fone KC. Reversal of a cholinergic-induced deficit in a rodent model of recognition memory by the selective 5-HT6 receptor antagonist, Ro 04-6790. Psychopharmacology (Berlin). 2003 Dec;170(4):358-67. PMID 13680084

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