Eletriptan

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Eletriptan
(IUPAC) ime
(R)-3-[(-1-metilprolidin-2-il)metil]-5-(2-fenilsulfoniletil)- 1H-indol
Klinički podaci
Robne marke Relpax
AHFS/Drugs.com Monografija
MedlinePlus a603029
Identifikatori
CAS broj 143322-58-1
ATC kod N02CC06
PubChem[1][2] 77993
DrugBank DB00216
ChemSpider[3] 70379
UNII 22QOO9B8KI YesY
KEGG[4] D01973 YesY
ChEBI CHEBI:50922 YesY
ChEMBL[5] CHEMBL1510 YesY
Hemijski podaci
Formula C22H26N2O2S 
Mol. masa 382,52 g/mol
SMILES eMolekuli & PubHem
Farmakokinetički podaci
Bioraspoloživost 50%
Metabolizam CYP3A4
Poluvreme eliminacije 4 sata
Farmakoinformacioni podaci
Trudnoća C(US)
Pravni status Prescription only
Način primene oralnot

Eletriptan (Relpaks, Relert) je član druge generacije triptanski lekova namenjenih tretmanu migrenske glavobolje. On se korist kao blokiranje migrenskih napada koji su već u toku.

FDA je odobrila eletriptan 2002 za akutni tretman migrene kod odraslih.[6] On je dostupan samo na recept u SAD-u k Kanadi. On nije namenjen za profilaktičku terapiju migrene ili za upotrebu u kontroli hemiplegične ili bazilarne migrene. Eletriptan je pokriven SAD patent 5545644[6][7] and SAD patent 6110940;[6][8] the FDA lists the patents as scheduled for expiration on December 26, 2016, and August 29, 2017, respectively.[6]

Reference[uredi - уреди | uredi izvor]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. PMID 20331846. doi:10.1186/1758-2946-2-3.  edit
  4. Joanne Wixon, Douglas Kell (2000). "Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG". Yeast 17 (1): 48–55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. 
  5. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100–7. PMID 21948594. doi:10.1093/nar/gkr777.  edit
  6. 6,0 6,1 6,2 6,3 FDA AccessData entry for Eletriptan Hydrobromide, accessed March 10, 2010.
  7. SAD patent 5545644, John E. Macor & Martin J. Wythes, Indole Derivatives, August 13, 1996.
  8. SAD patent 6110940, Valerie Denise Harding, et al., Salts of an anti-migraine indole derivative, August 29, 2000.

Spoljašnje veze[uredi - уреди | uredi izvor]


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