8-OH-DPAT
| 8-OH-DPAT | |||
|---|---|---|---|
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| IUPAC ime |
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| Naziv po klasifikaciji | 7-(Dipropilamino)-5,6,7,8-tetrahidronaftalen-1-ol[1] | ||
| Identifikacija | |||
| Abrevijacija | 8-OH-DPAT | ||
| CAS registarski broj | 78950-78-4 
| ||
| PubChem[2][3] | 1220, 6603866 (R), 10125797 (S) | ||
| ChemSpider[4] | 1183 , 5036174 (R) , 8301316 (S)
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| MeSH | |||
| ChEMBL[5] | CHEMBL56
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| IUPHAR ligand | 7 | ||
| Jmol-3D slike | Slika 1 Slika 2 | ||
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| Svojstva | |||
| Molekulska formula | C16H25NO | ||
| Molarna masa | 247.38 g mol−1 | ||
| log P | 3,711 | ||
| pKa | 10,539 | ||
| Baznost (pKb) | 3,458 | ||
| Farmakologija | |||
| Vreme polu-uklanjanja iz organizma | 1,5 sata | ||
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Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala | |||
| Infobox references | |||
8-OH-DPAT je istraživačka hemikalija iz aminotetralinske hemijske klase koja je razvijena tokom 1980-tih i široko korišćena u ispitivanju funkcije 5-HT1A receptora. On je bio jedan od prvih agonista) 5-HT1A receptora.
Originalno se verovalo da je selektivan za 5-HT1A receptor. Kasnije je utvrđeno da 8-OH-DPAT takođe deluje kao agonist 5-HT7 receptora i kao inhibitor serotoninskog preuzimanja/agens serotoninskog otpuštanja.[6][7][8][9][10]
Reference[uredi | uredi kod]
- ↑ „8-hydroxy-2-(di-N-propylamino)tetralin - PubChem Public Chemical Database”. The PubChem Project. USA: National Center for Biotechnology Information.
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.
- ↑ Larsson LG, Rényi L, Ross SB, Svensson B, Angeby-Möller K (February 1990). „Different effects on the responses of functional pre- and postsynaptic 5-HT1A receptors by repeated treatment of rats with the 5-HT1A receptor agonist 8-OH-DPAT”. Neuropharmacology 29 (2): 85–91. DOI:10.1016/0028-3908(90)90047-U. PMID 1691832.
- ↑ Sprouse J, Reynolds L, Li X, Braselton J, Schmidt A (January 2004). „8-OH-DPAT as a 5-HT7 agonist: phase shifts of the circadian biological clock through increases in cAMP production”. Neuropharmacology 46 (1): 52–62. DOI:10.1016/j.neuropharm.2003.08.007. PMID 14654097.
- ↑ „IUPHAR DATABASE - 5-Hydroxytryptamine receptors - 5-HT7”. Arhivirano iz originala na datum 2016-03-03. Pristupljeno 2014-04-11.
- ↑ Assié MB, Koek W (November 1996). „Possible in vivo 5-HT reuptake blocking properties of 8-OH-DPAT assessed by measuring hippocampal extracellular 5-HT using microdialysis in rats”. British Journal of Pharmacology 119 (5): 845–50. PMC 1915946. PMID 8922730.
- ↑ Wölfel R, Graefe KH (February 1992). „Evidence for various tryptamines and related compounds acting as substrates of the platelet 5-hydroxytryptamine transporter”. Naunyn-Schmiedeberg's Archives of Pharmacology 345 (2): 129–36. DOI:10.1007/BF00165727. PMID 1570019.