E-6801

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E-6801
E 6801.svg
IUPAC ime
Identifikacija
PubChem[1][2] 10202564
ChemSpider[3] 8378062 YesY
ChEMBL[4] CHEMBL362628 YesY
Jmol-3D slike Slika 1
Svojstva
Molekulska formula C17H18ClN5O2S2
Molarna masa 423,94 g mol-1



Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala

Infobox references

E-6801 je parcijalni agonist 5-HT6 receptora.[5] On poboljšava memoriju prepoznavanja i poništava memorijski deficit uzrokovan skopolaminom kod pacova u modelima prepoznavanja objekata.[6] Mehanizam memorijskog poboljšanja je baziran na kombinovanoj modulaciji holinergičke i glutamatergičkie neurotransmisije.

Reference[uredi - уреди | uredi izvor]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. PMID 20331846. doi:10.1186/1758-2946-2-3.  edit
  4. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100–7. PMID 21948594. doi:10.1093/nar/gkr777.  edit
  5. Romero, G. (August 2006). "Efficacy of selective 5-HT6 receptor ligands determined by monitoring 5-HT6 receptor-mediated cAMP signaling pathways". British Journal of Pharmacology 148 (8): 1133–43. PMC 1752021. PMID 16865095. doi:10.1038/sj.bjp.0706827. Pristupljeno 2011-12-24. 
  6. Kendall, I. (February 2011). "E-6801, a 5-HT6 receptor agonist, improves recognition memory by combined modulation of cholinergic and glutamatergic neurotransmission in the rat.". Psychopharmacology 213 (2-3): 413–30. PMID 20405281. 

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