Alnespiron

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Alnespiron
(IUPAC) ime
(+)-4-dihidro-2H-hromen-3-il]-propilamino]butil]-8-azaspiro[4.5]dekan-7,9-dion
Klinički podaci
Identifikatori
CAS broj 143413-68-7
ATC kod nije dodeljen
PubChem[1][2] 178132
ChemSpider[3] 8002134
UNII 34E28BM822 YesY
Hemijski podaci
Formula C26H38N2O4 
Mol. masa 442,589 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća  ?
Pravni status

Alnespiron (S-20,499) je selektivni pun agonist 5-HT1A receptora iz azapironske hemijske klase.[4][5][6] On ima antidepresivne i anksiolitičke efekte.[4]

Reference[uredi - уреди | uredi izvor]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. PMID 20331846. doi:10.1186/1758-2946-2-3.  edit
  4. 4,0 4,1 Griebel G, Misslin R, Pawlowski M, Guardiola Lemaître B, Guillaumet G, Bizot-Espiard J. (1992). "Anxiolytic-like effects of a selective 5-HT1A agonist, S20244, and its enantiomers in mice.". Neuroreport. 3 (1): 84–86. PMID 1351756. doi:10.1097/00001756-199201000-00022. 
  5. Simon P, Guardiola B, Bizot-Espiard J, Schiavi P, Costentin J. (1992). "5-HT1A receptor agonists prevent in rats the yawning and penile erections induced by direct dopamine agonists.". Psychopharmacology (Berl). 108 (1-2): 47–50. PMID 1357709. doi:10.1007/BF02245284. 
  6. Astier B, Lambás Señas L, Soulière F, Schmitt P, Urbain N, Rentero N, Bert L, Denoroy L, Renaud B, Lesourd M, Muñoz C, Chouvet G. (2003). "In vivo comparison of two 5-HT1A receptors agonists alnespirone (S-20499) and buspirone on locus coeruleus neuronal activity.". Eur J Pharmacol. 459 (1): 17–26. PMID 12505530. doi:10.1016/S0014-2999(02)02814-5. 

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