Kanabidiol

Iz Wikipedije, slobodne enciklopedije
Kanabidiol
(IUPAC) ime
2-[(1R,6R)-6-izopropenil-3-metilcikloheks-2-en-1-il]-5-pentilbenzen-1,3-diol
Klinički podaci
AHFS/Drugs.com Internacionalno ime leka
Identifikatori
CAS broj 13956-29-1
ATC kod nije dodeljen
PubChem[1][2] 644019
DrugBank none
ChemSpider[3] 24593618
UNII 19GBJ60SN5 YesY
Hemijski podaci
Formula C21H30O2 
Mol. masa 314,46
SMILES eMolekuli & PubHem
Fizički podaci
Tačka topljenja 66 °C (151 °F)
Tačka ključanja 180 °C (356 °F)
(Opseg: 160 °C-180 °C)[4]
Farmakoinformacioni podaci
Trudnoća  ?
Pravni status Plan II (Kanada)

Kanabidiol (CBD) je kanabinoid prisutan u kanabisu. On je glavni sastojak biljke, koji sačinjava do 40% njenog ekstrakta.[5]

On pokazuje sedativno dejstvo u testovima na životinjama.[6] Neka istraživanja, međutim, indiciraju da CBD može da poveća budnost.[7] On može da umanji brzinu uklanjanja THC-a iz tela, verovatno putem ometanja metabolizma THC-a u jetri.

Pokazano je da omanjuje konvulzije, inflamaciju, anksioznost, i mučninu, kao i da inhibira rast ćelija kancera.[8] Nedavne studije su pokazale da je kanabidiol efektivan kao atipični antipsihotik u tretmanu šizofrenije.[9] Ispitivanja su takođe pokazala da olakšava simptome distonije.[10][11]

Novembera 2007. je objavljeno da CBD redukuje rast agresivnih ljudskih ćelija raka dojke in vitro i da umanjuje njihovu invazivnost.

References[uredi - уреди | uredi izvor]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. PMID 20331846. doi:10.1186/1758-2946-2-3.  edit
  4. McPartland, JM; Russo, EB (2001). "Cannabis and Cannabis Extracts: Greater Than the Sum of Their Parts?" (PDF). Journal of Cannabis Therapeutics 1 (3/4): 103–132. 
  5. Grlić, Ljubiša (1962). "A comparative study on some chemical and biological characteristics of various samples of cannabis resin". Bulletin on Narcotics (United Nations Office on Drugs and Crime) (3): 37–46. 
  6. Pickens JT (1981). "Sedative activity of cannabis in relation to its delta'-trans-tetrahydrocannabinol and cannabidiol content". British Journal of Pharmacology 72 (4): 649–56. PMC 2071638. PMID 6269680. 
  7. Nicholson, AN; C Turner, BM Stone, and PJ Robson (June 2004). "Effect of Delta-9-tetrahydrocannabinol and cannabidiol on nocturnal sleep and early-morning behavior in young adults" (FEE REQUIRED). J Clin Psychopharmacol 24 (3): 305–13. ISSN 0271-0749. PMID 15118485. doi:10.1097/01.jcp.0000125688.05091.8f. Pristupljeno 2007-05-03. 
  8. Mechoulam, R.; M. Peters, Murillo-Rodriguez (21 Aug 2007). "Cannabidiol - recent advances". Chemistry & Biodiversity 4 (8): 1678–1692. PMID 17712814. doi:10.1002/cbdv.200790147.  Check date values in: |date= (help)
  9. Zuardi, A.W; J.A.S. Crippa, J.E.C. Hallak, F.A. Moreira, F.S. Guimarães (2006). "Cannabidiol, a Cannabis sativa constituent, as an antipsychotic drug" (PDF). Brazilian Journal of Medical and Biological Research 39 (4): 421–429. PMID 16612464. doi:10.1590/S0100-879X2006000400001. 
  10. Consroe, P.; Sandyk, R.; Snider, S. R. (1986). "Open label evaluation of cannabidiol in dystonic movement disorders". The International journal of neuroscience 30 (4): 277–282. PMID 3793381. doi:10.3109/00207458608985678. 
  11. Snider, Stuart R.; Consroe, Paul (1985). "Beneficial and Adverse Effects of Cannabidiol in a Parkinson Patient with Sinemet-Induced Dystonic Dyskinesia". Neurology (Suppl 1): 201. 

Vidi još[uredi - уреди | uredi izvor]

Spoljašnje veze[uredi - уреди | uredi izvor]

  • Erowid Compounds found in Cannabis sativa