Deksanabinol
(IUPAC ) ime
(6aS,10aS)-9-(Hidroksimetil)- 6,6-dimetil- 3-(2-metiloktan-2-il)- 6a,7,10,10a-tetrahidrobenzo [c]hromen-1-ol
Klinički podaci
Identifikatori
CAS broj
112924-45-5
ATC kod
nije dodeljen
PubChem [1] [2]
107778
ChemSpider [3]
96934
UNII
R6VT8U5372 Y
Hemijski podaci
Formula
C 25 H 38 O 3
Mol. masa
386,567 g/mol
SMILES
eMolekuli & PubHem
InChI
InChI=1S/C25H38O3/c1-6-7-8-9-12-24(2,3)18-14-21(27)23-19-13-17(16-26)10-11-20(19)25(4,5)28-22(23)15-18/h10,14-15,19-20,26-27H,6-9,11-13,16H2,1-5H3/t19-,20-/m0/s1 Y Key: SSQJFGMEZBFMNV-PMACEKPBSA-N Y
Farmakoinformacioni podaci
Trudnoća
?
Pravni status
Deksanabinol (HU-211 , ETS2101 [4] ) je sintetički kanabinoidni derivat koji je „neprirodni“ enantiomer potentnog kanabinoidnog agonista HU-210 .[5] Za razliku od kanabinoidnih derivata, HU-211 ne deluje kao agonist kanabinoidnog receptora , nego kao NMDA antagonist .[6] On stoga ne proizvodi kanabisu slične efekte, ali je antikonvulsant i neuroprotektivan, te nalazi široku primenu u naučnim istraživanjima. On se takođe izučava za moguću primenu u tretmanu povrede glave, moždanog udara i kancera.[7] [8] [9] Klinička istraživanja su pokazala da je bezbedan.[10] [11]
↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery." . Drug Discov Today 15 (23-24): 1052-7. DOI :10.1016/j.drudis.2010.10.003 . PMID 20970519 . http://www.sciencedirect.com/science/article/pii/S1359644610007737 . edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4 : 217-241. DOI :10.1016/S1574-1400(08)00012-1 .
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining" . J Cheminform 2 (1): 3. DOI :10.1186/1758-2946-2-3 . PMID 20331846 . http://www.jcheminf.com/content/2/1/3 . edit
↑ e-therapeutics Clinical Development Pipeline
↑ Pop E (September 2000). "Nonpsychotropic synthetic cannabinoids". Current Pharmaceutical Design 6 (13): 1347–60. DOI :10.2174/1381612003399446 . PMID 10903397 .
↑ Feigenbaum JJ, et al. (December 1989). "Nonpsychotropic cannabinoid acts as a functional N-methyl-D-aspartate receptor blocker" . Proceedings of the National Academy of Sciences of the United States of America 86 (23): 9584–7. DOI :10.1073/pnas.86.23.9584 . PMC 298542 . PMID 2556719 . //www.ncbi.nlm.nih.gov/pmc/articles/PMC298542/ .
↑ Biegon A; Joseph AB (August 1995). "Development of HU-211 as a neuroprotectant for ischemic brain damage". Neurological Research 17 (4): 275–80. PMID 7477742 .
↑ Darlington CL (October 2003). "Dexanabinol: a novel cannabinoid with neuroprotective properties". IDrugs : the Investigational Drugs Journal 6 (10): 976–9. PMID 14534855 .
↑ Vink R; Nimmo AJ (January 2009). "Multifunctional drugs for head injury". Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics 6 (1): 28–42. DOI :10.1016/j.nurt.2008.10.036 . PMID 19110197 .
↑ Maas AI, et al. (January 2006). "Efficacy and safety of dexanabinol in severe traumatic brain injury: results of a phase III randomised, placebo-controlled, clinical trial". Lancet Neurol 5 (1): 38–45. DOI :10.1016/S1474-4422(05)70253-2 . PMID 16361021 .
↑ University of California, San Diego "Synthetic Cannabinoid May Be Used as Brain Cancer Treatment ". (28 September 2012) Laboratory Equipment . Retrieved 28 September 2012.
Jonotropni
Agonisti: Konkurentni agonisti :
Aspartat • Glutamat • Homokinolinska kiselina • Ibotenska kiselina • NMDA • Kinolinska kiselina • Tetrazolilglicin ;
Agonisti glicinskog mesta: ACBD • ACPC • ACPD • Alanin • CCG • Cikloserin • DHPG • Fluoroalanin • Glicin • HA-966 • L-687,414 • Milacemid • Sarkozin • Serin • Tetrazolilglicin ;
Agonisti poliaminskog mesta: Akamprosat • Spermidin • Spermin Antagonisti : Konkurentni antagonisti: AP5 (APV) • AP7 • CGP-37849 • CGP-39551 • CGP-39653 • CGP-40116 • CGS-19755 • CPP • LY-233,053 • LY-235,959 • LY-274,614 • MDL-100,453 • Midafotel (d-CPPen) • NPC-12,626 • NPC-17,742 • PBPD • PEAQX • Perzinfotel • PPDA • SDZ-220581 • Selfotel ;
Nekonkurentni antagonisti: ARR-15,896 • Karoverin • Deksanabinol • FPL-12495 • FR-115,427 • Hodgkinsin • Magnezijum • MDL-27,266 • NPS-1506 • Psihotridin • Cink ;
Nekonkurentni blokatori pora: 2-MDP • 3-MeO-PCP • 8A-PDHQ • Amantadin • Aptiganel • ARL-12,495 • ARL-15,896-AR • ARL-16,247 • Budipin • Delucemin • Deksoksadrol • Dekstralorfan • Dieticiklidin • Dizocilpin • Endopsihozin • Esketamin • Etoksadrol • Eticiklidin • Gaciklidin • Ibogain • Indantadol • Ketamin • Ketobemidon • Loperamid • Memantin • Meperidin (Petidin) • Metadon • Metorfan (
Dekstrometorfan ,
Levometorfan )
• Metoksetamin • Milnacipran • Morfanol (
Dekstrorfan ,
Levorfanol )
• NEFA • Nerameksan • Azotsuboksid • Noribogain • Orfenadrin • PCPr • Fenciklamin • Fenciklidin • Propoksifen • Remacemid • Rinhofilin • Riluzol • Rimantadin • Roliciklidin • Sabeluzol • Tenociklidin • Tiletamin • Tramadol • Ksenon ;
Antagonisti glicinskog mesta: ACEA-1021 • ACEA-1328 • ACPC • Karisoprodol • CGP-39653 • CKA • DCKA • Felbamat • Gavestinel • GV-196,771 • Kinurenska kiselina • L-689,560 • L-701,324 • Lakosamid • Likostinel • LU-73,068 • MDL-105,519 • Meprobamat • MRZ 2/576 • PNQX • ZD-9379 ;
Antagonisti NR2B podjedinice: Bezonprodil • CO-101,244 (PD-174,494) • CP-101,606 • Eliprodil • Haloperidol • Ifenprodil • Izoksuprin • Nilidrin • Ro8-4304 • Ro25-6981 • Traksoprodil ;
Neklasifikovani/nesortirani antagonisti: Hloroform • Dietil etar • Enfluran • Etanol (Alkohol) • Halotan • Izofluran • Metoksifluran • Toluen • Trihloroetan • Trihloroetanol • Trihloroetilen • Ksilen
Metabotropni
Inhibitori transporta
Šablon:Kanabinoidi
Molimo Vas, obratite pažnju na važno upozorenje u vezi tema o zdravlju (medicini) .