PEPA (lek)

Izvor: Wikipedia
PEPA (lek)
(IUPAC) ime
2-[2,6-difluoro-4-({2-[(fenilsulfonil)amino]etil}tio)fenoksi]acetamid
Klinički podaci
Identifikatori
CAS broj 141286-78-4
ATC kod nije dodeljen
PubChem[1][2] 6603828
Hemijski podaci
Formula C16H16F2N2O4S2 
Mol. masa 402.436 g/mol
SMILES eMolekuli & PubHem
Sinonimi PEPA
Farmakoinformacioni podaci
Trudnoća  ?
Pravni status Lek u razvoju

PEPA je ampakinski lek koji deluje kao alosterni potencijator desenzitizacije AMPA receptora.[3][4] On je oko 100 puta potentniji od aniracetama in vitro.[5] It produces memory-enhancing effects in rats when administered intravenously.[6]

Reference[uredi - уреди]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. doi:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Sekiguchi M, Takeo J, Harada T, Morimoto T, Kudo Y, Yamashita S, Kohsaka S, Wada K (1998). "Pharmacological detection of AMPA receptor heterogeneity by use of two allosteric potentiators in rat hippocampal cultures". British Journal of Pharmacology 123 (7): 1294–303. doi:10.1038/sj.bjp.0701707. PMC 1565288. PMID 9579722. 
  4. Sekiguchi, M; Nishikawa, K; Aoki, S; Wada, K (2002). "A desensitization-selective potentiator of AMPA-type glutamate receptors". British Journal of Pharmacology 136 (7): 1033–41. doi:10.1038/sj.bjp.0704804. PMC 1573432. PMID 12145103.  More than one of |last1= and |author= specified (help)
  5. Sekiguchi, M; Fleck, MW; Mayer, ML; Takeo, J; Chiba, Y; Yamashita, S; Wada, K (1997). "A novel allosteric potentiator of AMPA receptors: 4--2-(phenylsulfonylamino)ethylthio--2,6-difluoro-phenoxyaceta mide". Journal of Neuroscience 17 (15): 5760–71. PMID 9221774. 
  6. Sekiguchi, M; Yamada, K; Jin, J; Hachitanda, M; Murata, Y; Namura, S; Kamichi, S; Kimura, I et al. (2001). "The AMPA receptor allosteric potentiator PEPA ameliorates post-ischemic memory impairment". NeuroReport 12 (13): 2947–50. doi:10.1097/00001756-200109170-00038. PMID 11588608. 

Spoljašnje veze[uredi - уреди]


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