LY-307,452 je lek koji se koristi u naučnim istraživanjima. On je bio među prvim jedinjenjima koja su delovala kao selektivni antagonisti za grupu II metabotropnih glutamatnih receptora (mGluR2/3),[3] i bio je koristan u ranim ispitivanjima te receptorske familije,[4][5] mada je u međuvremenu uglavnom zamenjen novijim lekovima poput LY-341,495.
↑Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑Wermuth CG, Mann A, Schoenfelder A, Wright RA, Johnson BG, Burnett JP, Mayne NG, Schoepp DD (February 1996). „(2S,4S)-2-amino-4-(4,4-diphenylbut-1-yl)-pentane-1,5-dioic acid: a potent and selective antagonist for metabotropic glutamate receptors negatively linked to adenylate cyclase”. Journal of Medicinal Chemistry39 (4): 814–6. DOI:10.1021/jm9508144. PMID8632404.
↑Sung KW, Choi S, Lovinger DM (November 2001). „Activation of group I mGluRs is necessary for induction of long-term depression at striatal synapses”. Journal of Neurophysiology86 (5): 2405–12. PMID11698530.