1-Amino-1,3-dikarboksiciklopentan

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1-Amino-1,3-dikarboksiciklopentan
Stereo, skeletal formula of ACPD ((1S,3S)-1-amino,-1,3-dicarboxylic acid)
Naziv po klasifikaciji 1-Aminociklopentan-1,3-dikarboksilna kiselina[1]
Identifikacija
Abrevijacija ACPD
CAS registarski broj 39026-63-6 YesY, 56827-69-1 (1R,3S), 111900-32-4 (1S,3R)
PubChem[2][3] 1310
44381972 (1S)
231345 (1R,3R)
73537 (1R,3S)
104766 (1S,3R)
6604704 (1S,3S)
ChemSpider[4] 5036967 (1S,3S) YesY, 201559 (1R,3R) YesY, 66220 (1R,3S) YesY, 94574 (1S,3R) YesY
MeSH 1-amino-1,3-dicarboxycyclopentane
ChEMBL[5] CHEMBL168278 YesY
RTECS registarski broj toksičnosti GY4060000 (1S,3R)
Jmol-3D slike Slika 1
Svojstva
Molekulska formula C7H11NO4
Molarna masa 173.17 g mol−1
Agregatno stanje Beli kristali
Rastvorljivost u vodi 20 g dm-3
Rastvorljivost u etanol 240 mg dm-3
log P -0,709
pKa 2,112
Baznost (pKb) 11,885
Izoelektrična tačka 2,84
Opasnost
EU-klasifikacija Harmful Xn
R-oznake R20/21/22, R36/37/38
S-oznake S26, S36/37

 YesY (šta je ovo?)   (verifikuj)

Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala

Infobox references

1-Amino-1,3-dikarboksiciklopentan (ACPD) je hemijsko jedinjenje koje se vezuje za metabotropni glutamatni receptor (mGluR).[6] ACPD deluje kao mGluR agonist. On je krut analog neurotransmitera glutamata koji ne aktivira jonotropne glutamatne receptore.[7] ACPD može da indukuje konvulzije kod neonatalnih pacova.[8]

Reference[uredi - уреди | uredi izvor]

  1. "1-amino-1,3-dicarboxycyclopentane - Compound Summary". PubChem Compound. USA: National Center for Biotechnology Information. 25. 3. 2005.. Identification and Related Records. http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=1310. pristupljeno 15. 10. 2011.. 
  2. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  3. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  4. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. PMID 20331846. doi:10.1186/1758-2946-2-3.  edit
  5. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100–7. PMID 21948594. doi:10.1093/nar/gkr777.  edit
  6. Schoepp DD, True RA (September 1992). "1S,3R-ACPD-sensitive (metabotropic) [3H]glutamate receptor binding in membranes". Neurosci. Lett. 145 (1): 100–4. PMID 1461560. doi:10.1016/0304-3940(92)90213-Q. 
  7. Manzoni O, Fagni L, Pin JP, Rassendren F, Poulat F, Sladeczek F, Bockaert J (July 1990). "(trans)-1-amino-cyclopentyl-1,3-dicarboxylate stimulates quisqualate phosphoinositide-coupled receptors but not ionotropic glutamate receptors in striatal neurons and Xenopus oocytes". Mol. Pharmacol. 38 (1): 1–6. PMID 2164627. 
  8. McDonald JW, Fix AS, Tizzano JP, Schoepp DD (October 1993). "Seizures and brain injury in neonatal rats induced by 1S,3R-ACPD, a metabotropic glutamate receptor agonist". J. Neurosci. 13 (10): 4445–55. PMID 8410197.