Sarkozin

Sarkozin
	2-(Metilamino)sirćetna kiselina
Identifikacija
CAS registarski broj	107-97-1
PubChem	1088
ChemSpider	1057
UNII	Z711V88R5F
EINECS broj	203-538-6
KEGG	C00213
ChEBI	15611
ChEMBL	CHEMBL304383
Bajlštajn	1699442
Gmelin Referenca	2018
3DMet	B01190
Jmol-3D slike	Slika 1; Slika 2
SMILES
	CNCc(:[o]):[oH] CNCC(O)=O
InChI
	InChI=1S/C3H7NO2/c1-4-2-3(5)6/h4H,2H2,1H3,(H,5,6) ; Kod: FSYKKLYZXJSNPZ-UHFFFAOYSA-N
Svojstva
Molekulska formula	C3H7NO2
Molarna masa	89.09 g mol−1
Agregatno stanje	Beli kristali
Miris	Bez mirisa
Rastvorljivost u vodi	89,09 g L−1 (na 20 °C)
log P	0,599
pKa	2,36
Baznost (pKb)	11,64
λmax	260 nm
Apsorbancija	0,05
Termohemija
Standardna entalpija stvaranja jedinjenja ΔfHo298	−513,50 – 512.98 kJ mol−1
Std entalpija; sagorevanja ΔcHo298	−1667,84 – 1667.54 kJ mol−1
Specifični toplotni kapacitet, C	128,9 J K−1 mol−1
Srodna jedinjenja
Srodna alkanoinske kiseline	Dimetilglicin; Glikociamin; Kreatin; N-Metil-D-aspartinska kiselina; beta-Metilamino-L-alanin; Guanidinopropionska kiselina;
Srodna jedinjenja	Dimetilacetamid
	(šta je ovo?) (verifikuj) ; Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala
	Infobox references

Sarkozin (N-metilglicin) je intermedijer i nusproizvod u sintezi i degradaciji glicina. Sarcozin se metaboliše do glicina enzimom sarkozin dehidrogenaza, kod glicin-N-metil transferaza generariše sarkozin iz glicina. Sarkozin je prirodna aminokiselina prisutna u mišićnim i drugim telesnim tkivima. U laboratoriji se može sintetisati iz hlorosirćetne kiseline i metilamina. Sarkozin ima sladak ukus i rastvara se u vodi. On se koristi u proizvodnji biorazgradivih surfaktanata i pasti za zube, i za niz drugih oblika primena.

Sarkozin je sveptisutan u biološkim materijalima i u hrani poput žumanceta, ćuretine, šunke, povrća, mahuna, etc. Sarkozin se formira iz holina unesenog hranom i metabolizmom metionina. On se brzo razlaže do glicina. Koncentracija sarkozina u krvnom serum prosečne osobe je 1,59 ± 1,08 nM.^[7]

Reference[uredi - уреди | uredi izvor]

↑ "Sarcosine - Compound Summary". PubChem Compound. USA: National Center for Biotechnology Information. 16. 9. 2004.. Identification. http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=1088&loc=ec_rcs#x291. Pristupljeno 21. 4. 2012..
↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. http://www.sciencedirect.com/science/article/pii/S1359644610007737. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. http://www.jcheminf.com/content/2/1/3. edit
↑ Joanne Wixon, Douglas Kell (2000). "Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG". Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. http://onlinelibrary.wiley.com/doi/10.1002/%28SICI%291097-0061%28200004%2917:1%3C48::AID-YEA2%3E3.0.CO;2-H/full.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Allen, RH; Stabler, SP; Lindenbaum, J (1993). "Serum betaine, N,N-dimethylglycine and N-methylglycine levels in patients with cobalamin and folate deficiency and related inborn errors of metabolism". Metabolism: clinical and experimental 42 (11): 1448–60. DOI:10.1016/0026-0495(93)90198-W. PMID 7694037.

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[1] "Sarcosine - Compound Summary". PubChem Compound. USA: National Center for Biotechnology Information. 16. 9. 2004.. Identification. http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=1088&loc=ec_rcs#x291. Pristupljeno 21. 4. 2012..

[2] Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. http://www.sciencedirect.com/science/article/pii/S1359644610007737. edit

[3] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[4] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. http://www.jcheminf.com/content/2/1/3. edit

[5] Joanne Wixon, Douglas Kell (2000). "Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG". Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. http://onlinelibrary.wiley.com/doi/10.1002/%28SICI%291097-0061%28200004%2917:1%3C48::AID-YEA2%3E3.0.CO;2-H/full.

[6] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[7] Allen, RH; Stabler, SP; Lindenbaum, J (1993). "Serum betaine, N,N-dimethylglycine and N-methylglycine levels in patients with cobalamin and folate deficiency and related inborn errors of metabolism". Metabolism: clinical and experimental 42 (11): 1448–60. DOI:10.1016/0026-0495(93)90198-W. PMID 7694037.

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Sarkozin

Reference[uredi - уреди | uredi izvor]

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