Glicin N-metiltransferaza
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| Glicin N-metiltransferaza | |||||||||
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| Identifikatori | |||||||||
| EC broj | 2.1.1.20 | ||||||||
| CAS broj | 37228-72-1 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Glicin N-metiltransferaza (EC 2.1.1.20, glicinska metiltransferaza, S-adenozil-L-metionin:glicin metiltransferaza, GNMT) je enzim sa sistematskim imenom S-adenozil-L-metionin:glicin N-metiltransferaza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
Ovaj enzim učestvuje u regulaciji metabolizma metil grupe u jetri i pankreasu putem regulacije odnosa između S-adenozil-L-metionina i S-adenozil-L-homocisteina.
Reference[uredi | uredi kod]
- ↑ Blumenstein, J. and Williams, G.R. (1963). „Glycine methyltransferase”. Can. J. Biochem. Physiol. 41: 201-210. PMID 13971907.
- ↑ Ogawa, H., Gomi, T., Takusagawa, F. and Fujioka, M. (1998). „Structure, function and physiological role of glycine N-methyltransferase”. Int. J. Biochem. Cell Biol. 30: 13-26. PMID 9597750.
- ↑ Yeo, E.J., Briggs, W.T. and Wagner, C. (1999). „Inhibition of glycine N-methyltransferase by 5-methyltetrahydrofolate pentaglutamate”. J. Biol. Chem. 274: 37559-37564. PMID 10608809.
- ↑ Martinov, M.V., Vitvitsky, V.M., Mosharov, E.V., Banerjee, R. and Ataullakhanov, F.I. (2000). „A substrate switch: a new mode of regulation in the methionine metabolic pathway”. J. Theor. Biol. 204: 521-532. PMID 10833353.
- ↑ Takata, Y., Huang, Y., Komoto, J., Yamada, T., Konishi, K., Ogawa, H., Gomi, T., Fujioka, M. and Takusagawa, F. (2003). „Catalytic mechanism of glycine N-methyltransferase”. Biochemistry 42: 8394-8402. PMID 12859184.
- ↑ Pakhomova, S., Luka, Z., Grohmann, S., Wagner, C. and Newcomer, M.E. (2004). „Glycine N-methyltransferases: a comparison of the crystal structures and kinetic properties of recombinant human, mouse and rat enzymes”. Proteins 57: 331-337. PMID 15340920.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.