HU-210

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HU-210
(IUPAC) ime
(6aR,10aR)- 9-(Hidroksimetil)- 6,6-dimetil- 3-(2-metiloktan-2-il)- 6a,7,10,10a-tetrahidrobenzo [c]hromen- 1-ol
Klinički podaci
Identifikatori
CAS broj 112830-95-2
ATC kod nije dodeljen
PubChem[1][2] 9821569
ChemSpider[3] 21106322
ChEMBL[4] CHEMBL70625 YesY
Hemijski podaci
Formula C25H38O3 
Mol. masa 386,567 g/mol
SMILES eMolekuli & PubHem
Sinonimi 1,1-Dimetilheptil- 11-hidroksi- tetrahidrokanabinol
Farmakoinformacioni podaci
Trudnoća  ?
Pravni status Plan I kontrolisana supstanca u SAD[5]

HU-210 je sintetički kanabinoid koji je prvi put sintetisan 1988. iz (1R,5S)-mirtenol]]a[6][7][8][9] HU-210 je 100 do 800 puta potentniji od prirodnog THC iz kanabisa i ima duže vreme dejstva.[10] HU-210 je (–)-1,1-dimetilheptil analog 11-hidroksi- Δ8- tetrahidrokanabinola.

Drugi HU kanabinoidi[uredi - уреди | uredi izvor]

Vidi još[uredi - уреди | uredi izvor]

Reference[uredi - уреди | uredi izvor]

  1. ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  2. ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. PMID 20331846. doi:10.1186/1758-2946-2-3.  edit
  4. ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100–7. PMID 21948594. doi:10.1093/nar/gkr777.  edit
  5. ↑ Controlled Substances
  6. ↑ Mechoulam, R., Lander, N., Breuer, A., Zahalka, J. Synthesis of the Individual, Pharmacologically Distinct, Enantiomers of a Tetrahydrocannabinol Derivative. Tetrahedron: Asymmetry. 1990. Vol 1, No 5. pp 315-318.
  7. ↑ Mechoulam, R. et al. (1988). "Enantiomeric cannabinoids: stereospecificity of psychotropic activity". Experientia 44 (9): 762–764. PMID 3416993. doi:10.1007/BF01959156. 
  8. ↑ Little PJ, Compton DR, Mechoulam R, Martin BR. Stereochemical effects of 11-OH-Δ8-THC-dimethylheptyl in mice and dogs. Pharmacology, Biochemistry, and Behavior. 1989 Mar;32(3):661-666.
  9. ↑ Järbe, T.; Hiltunen, A.; Mechoulam, R. (1989). "Stereospecificity of the discriminative stimulus functions of the dimethylheptyl homologs of 11-hydroxy-delta 8-tetrahydrocannabinol in rats and pigeons". The Journal of Pharmacology and Experimental Therapeutics 250 (3): 1000–1005. PMID 2550611. 
  10. ↑ Devane, W. A. et al. (1992). "A novel probe for the cannabinoid receptor". Journal of Medical Chemistry 35 (11): 2065–2069. PMID 1317925. doi:10.1021/jm00089a018. 

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