HU-210

HU-210
(IUPAC) ime
	(6aR,10aR)- 9-(Hidroksimetil)- 6,6-dimetil- 3-(2-metiloktan-2-il)- 6a,7,10,10a-tetrahidrobenzo [c]hromen- 1-ol
Klinički podaci
Identifikatori
CAS broj	112830-95-2
ATC kod	nije dodeljen
PubChem	9821569
ChemSpider	21106322
ChEMBL	CHEMBL70625
Hemijski podaci
Formula	C25H38O3
Mol. masa	386,567 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C25H38O3/c1-6-7-8-9-12-24(2,3)18-14-21(27)23-19-13-17(16-26)10-11-20(19)25(4,5)28-22(23)15-18/h13-15,19-20,26-27H,6-12,16H2,1-5H3/t19-,20-/m0/s1 ; Key: UEXRUIOOOVZHFZ-PMACEKPBSA-N
Sinonimi	1,1-Dimetilheptil- 11-hidroksi- tetrahidrokanabinol
Farmakoinformacioni podaci
Trudnoća	?
Pravni status	Plan I kontrolisana supstanca u SAD

HU-210 je sintetički kanabinoid koji je prvi put sintetisan 1988. iz (1R,5S)-mirtenol]]a^[6]^[7]^[8]^[9] HU-210 je 100 do 800 puta potentniji od prirodnog THC iz kanabisa i ima duže vreme dejstva.^[10] HU-210 je (–)-1,1-dimetilheptil analog 11-hidroksi- Δ⁸- tetrahidrokanabinola.

Drugi HU kanabinoidi

Povezano

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ „Controlled Substances”. Arhivirano iz originala na datum 2016-04-17. Pristupljeno 2014-04-05.
↑ Mechoulam, R., Lander, N., Breuer, A., Zahalka, J. Synthesis of the Individual, Pharmacologically Distinct, Enantiomers of a Tetrahydrocannabinol Derivative. Tetrahedron: Asymmetry. 1990. Vol 1, No 5. pp 315-318.
↑ Mechoulam, R., et al. (1988). „Enantiomeric cannabinoids: stereospecificity of psychotropic activity”. Experientia 44 (9): 762–764. DOI:10.1007/BF01959156. PMID 3416993.
↑ Little PJ, Compton DR, Mechoulam R, Martin BR. Stereochemical effects of 11-OH-Δ8-THC-dimethylheptyl in mice and dogs. Pharmacology, Biochemistry, and Behavior. 1989 Mar;32(3):661-666.
↑ Järbe, T.; Hiltunen, A.; Mechoulam, R. (1989). „Stereospecificity of the discriminative stimulus functions of the dimethylheptyl homologs of 11-hydroxy-delta 8-tetrahydrocannabinol in rats and pigeons”. The Journal of Pharmacology and Experimental Therapeutics 250 (3): 1000–1005. PMID 2550611.
↑ Devane, W. A., et al. (1992). „A novel probe for the cannabinoid receptor”. Journal of Medical Chemistry 35 (11): 2065–2069. DOI:10.1021/jm00089a018. PMID 1317925.

Spoljašnje veze

	Portal Medicina
	Portal Hemija

Comment in Nature on the article about neurogenesis.

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[5] „Controlled Substances”. Arhivirano iz originala na datum 2016-04-17. Pristupljeno 2014-04-05.

[6] Mechoulam, R., Lander, N., Breuer, A., Zahalka, J. Synthesis of the Individual, Pharmacologically Distinct, Enantiomers of a Tetrahydrocannabinol Derivative. Tetrahedron: Asymmetry. 1990. Vol 1, No 5. pp 315-318.

[7] Mechoulam, R., et al. (1988). „Enantiomeric cannabinoids: stereospecificity of psychotropic activity”. Experientia 44 (9): 762–764. DOI:10.1007/BF01959156. PMID 3416993.

[8] Little PJ, Compton DR, Mechoulam R, Martin BR. Stereochemical effects of 11-OH-Δ8-THC-dimethylheptyl in mice and dogs. Pharmacology, Biochemistry, and Behavior. 1989 Mar;32(3):661-666.

[9] Järbe, T.; Hiltunen, A.; Mechoulam, R. (1989). „Stereospecificity of the discriminative stimulus functions of the dimethylheptyl homologs of 11-hydroxy-delta 8-tetrahydrocannabinol in rats and pigeons”. The Journal of Pharmacology and Experimental Therapeutics 250 (3): 1000–1005. PMID 2550611.

[pmid1317925-10] Devane, W. A., et al. (1992). „A novel probe for the cannabinoid receptor”. Journal of Medical Chemistry 35 (11): 2065–2069. DOI:10.1021/jm00089a018. PMID 1317925.

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