AMG-1

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AMG-1
(IUPAC) ime
(6aR,10aR)-3-(hept-1-inil)-6,6,9-trimethil-6a,7,10,10a-tetrahydrobenzo[c]chromen-1-ol
Klinički podaci
Identifikatori
ATC kod ?
PubChem[1][2] 10830874
ChemSpider[3] 9006174
ChEMBL[4] CHEMBL279147 YesY
Hemijski podaci
Formula C23H30O2 
Mol. masa 338,482 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća ?
Pravni status

AMG-1 je analgetik koji je kanabinoidni agonist. On je derivat Δ8THC sa lancom u 3-poziciji bočnog lanca koji je očvršćen i produžen. AMG-1 je potentan agonist na CB1 i CB2 sa umerenom selektivnošću za CB1, pri čemu je Ki 0,6nM na CB1 vs 3,1 nM na CB2.[5]

Reference[uredi - уреди | uredi izvor]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. PMID 20331846. doi:10.1186/1758-2946-2-3.  edit
  4. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100–7. PMID 21948594. doi:10.1093/nar/gkr777.  edit
  5. Papahatjis DP, Nikas SP, Kourouli T, Chari R, Xu W, Pertwee RG, Makriyannis A. Pharmacophoric requirements for the cannabinoid side chain. Probing the cannabinoid receptor subsite at C1'. Journal of Medicinal Chemistry. 2003 Jul 17;46(15):3221-9. PMID 12852753


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