9-nor-9β-Hidroksiheksahidrokanabinol (HHC), je sintetički kanabinoidni derivat koji se formira modifikacijom strukture tetrahidrokanabinola. Ovo jedinjenje je originalno napravljeno u kontekstu potrage za najjednostavnijim jedinjenjem koje zadovoljava zahteve vezivanja za kanabinoidni receptor, čime se proizvodi kanabisu slična aktivnost.[3][4] HHC potentnost je slična sa THC. Dalja pojednostavljenja i varijacije ove strukture proizvode još potentnije molekule, kao što su CP 47,497 i CP 55,940.[5][6][7]
↑Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry4: 217–241. doi:10.1016/S1574-1400(08)00012-1.
↑Johnson MR, et al. Potent Analgetics Derived From 9-Nor-9β-Hydroxyhexahydrocannabinol. NIDA Research Monograph 34; 1980. pp 68-74.
↑Melvin LS, Johnson MR. Structure-Activity Relationships of Tricyclic and Nonclassical Bicyclic Cannabinoids. NIDA Research Monograph 79; 1987. pp 31-47.
↑Weissman, A; Milne, GM; Melvin Jr, LS (1982). "Cannabimimetic activity from CP-47,497, a derivative of 3-phenylcyclohexanol". The Journal of Pharmacology and Experimental Therapeutics223 (2): 516–23. PMID6290642.
↑Melvin, LS et al. (1984). "A cannabinoid derived prototypical analgesic". Journal of Medical Chemistry27 (1): 67–71. PMID6690685. doi:10.1021/jm00367a013.CS1 održavanje: Eksplicitna upotreba et al. (link)
↑Compton, DR; Johnson, MR; Melvin, LS; Martin, BR (1992). "Pharmacological profile of a series of bicyclic cannabinoid analogs: classification as cannabimimetic agents". The Journal of Pharmacology and Experimental Therapeutics260 (1): 201–9. PMID1309872.
