9-nor-9β-Hidroksiheksahidrokanabinol

9-*nor*-9β-Hidroksiheksahidrokanabinol
(IUPAC) ime
	6,6-dimetil-3-pentil-6a,7,8,9,10,10a-heksahidrobenzo[c]hromen-1,9-diol
Klinički podaci
Identifikatori
CAS broj	52171-85-4
ATC kod	nije dodeljen
PubChem	6452587
Hemijski podaci
Formula	C20H30O3
Mol. masa	318,449 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C20H30O3/c1-4-5-6-7-13-10-17(22)19-15-12-14(21)8-9-16(15)20(2,3)23-18(19)11-13/h10-11,14-16,21-22H,4-9,12H2,1-3H3 ; Key: AAIHVZNCFQTVCA-UHFFFAOYSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

9-nor-9β-Hidroksiheksahidrokanabinol (HHC), je sintetički kanabinoidni derivat koji se formira modifikacijom strukture tetrahidrokanabinola. Ovo jedinjenje je originalno napravljeno u kontekstu potrage za najjednostavnijim jedinjenjem koje zadovoljava zahteve vezivanja za kanabinoidni receptor, čime se proizvodi kanabisu slična aktivnost.^[3]^[4] HHC potentnost je slična sa THC. Dalja pojednostavljenja i varijacije ove strukture proizvode još potentnije molekule, kao što su CP 47,497 i CP 55,940.^[5]^[6]^[7]

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↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. http://www.sciencedirect.com/science/article/pii/S1359644610007737. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Johnson MR, et al. Potent Analgetics Derived From 9-Nor-9β-Hydroxyhexahydrocannabinol. NIDA Research Monograph 34; 1980. pp 68-74.
↑ Melvin LS, Johnson MR. Structure-Activity Relationships of Tricyclic and Nonclassical Bicyclic Cannabinoids. NIDA Research Monograph 79; 1987. pp 31-47.
↑ Weissman, A; Milne, GM; Melvin Jr, LS (1982). "Cannabimimetic activity from CP-47,497, a derivative of 3-phenylcyclohexanol". The Journal of Pharmacology and Experimental Therapeutics 223 (2): 516–23. PMID 6290642.
↑ Melvin, LS, et al. (1984). "A cannabinoid derived prototypical analgesic". Journal of Medical Chemistry 27 (1): 67–71. DOI:10.1021/jm00367a013. PMID 6690685.
↑ Compton, DR; Johnson, MR; Melvin, LS; Martin, BR (1992). "Pharmacological profile of a series of bicyclic cannabinoid analogs: classification as cannabimimetic agents". The Journal of Pharmacology and Experimental Therapeutics 260 (1): 201–9. PMID 1309872.

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. http://www.sciencedirect.com/science/article/pii/S1359644610007737. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Johnson MR, et al. Potent Analgetics Derived From 9-Nor-9β-Hydroxyhexahydrocannabinol. NIDA Research Monograph 34; 1980. pp 68-74.

[4] Melvin LS, Johnson MR. Structure-Activity Relationships of Tricyclic and Nonclassical Bicyclic Cannabinoids. NIDA Research Monograph 79; 1987. pp 31-47.

[5] Weissman, A; Milne, GM; Melvin Jr, LS (1982). "Cannabimimetic activity from CP-47,497, a derivative of 3-phenylcyclohexanol". The Journal of Pharmacology and Experimental Therapeutics 223 (2): 516–23. PMID 6290642.

[6] Melvin, LS, et al. (1984). "A cannabinoid derived prototypical analgesic". Journal of Medical Chemistry 27 (1): 67–71. DOI:10.1021/jm00367a013. PMID 6690685.

[7] Compton, DR; Johnson, MR; Melvin, LS; Martin, BR (1992). "Pharmacological profile of a series of bicyclic cannabinoid analogs: classification as cannabimimetic agents". The Journal of Pharmacology and Experimental Therapeutics 260 (1): 201–9. PMID 1309872.

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9-nor-9β-Hidroksiheksahidrokanabinol

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