AM-855

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AM-855
(IUPAC) ime
(4aR,12bR)-8-heksil-2,5,5-trimetil-1,4,4a,8,9,10,11,12b-oktahidronafto[3,2-c]izohromen-12-ol
Klinički podaci
Identifikatori
ATC kod ?
PubChem[1][2] 10091328
ChemSpider[3] 8266865
ChEMBL[4] CHEMBL303479 YesY
Hemijski podaci
Formula C26H38O2 
Mol. masa 382,577 g/mol-
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća ?
Pravni status

AM-855 je analgetik koji je kanabinoidni agonist. On je derivat Δ8Tetrahidrokanabinola sa konformaciono ograničenim bočnim lancom. AM-855 je agonist CB1 i CB2 sa umerenom selektivnošću za CB1, Ki od 22,3 nM na CB1 i 58,6 nM na CB2.[5]

References[uredi - уреди | uredi izvor]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. PMID 20331846. doi:10.1186/1758-2946-2-3.  edit
  4. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100–7. PMID 21948594. doi:10.1093/nar/gkr777.  edit
  5. Khanolkara, Atmaram D.; Dai Lua, Pusheng Fana, Xiaoyu Tiana and Alexandros Makriyannis (August 1999). "Novel conformationally restricted tetracyclic analogs of Δ8-tetrahydrocannabinol". Bioorganic & Medicinal Chemistry Letters 9 (15): 2119–24. PMID 10465529. doi:10.1016/S0960-894X(99)00355-8. 

Reference[uredi - уреди | uredi izvor]


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