A-41988

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A-41988
(IUPAC) ime
8-[5-(4-fluorofenil)pentan-2-il]-5,5-dimetil-2-prop-2-inil-3,4-dihidro-1H-hromeno[4,3-c]piridin-10-ol
Klinički podaci
Identifikatori
CAS broj 52763-30-1
ATC kod nije dodeljen
PubChem[1][2] 3085018
ChemSpider[3] 2341998
ChEMBL[4] CHEMBL303312 YesY
Hemijski podaci
Formula C28H32FNO2 
Mol. masa 433,556 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća ?
Pravni status

A-41988 (BW29Y) je analgetski lek koji deluje kao kanabinoidni agonist. Ovaj materija je razivala kompanija Abbott Laboratories tokom 1970-ih,[5][6] i istražila za potencijalnu primenu u tretmanu glaukoma.[7] Lek nije plasiran na tržište.

Reference[uredi - уреди | uredi izvor]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. PMID 20331846. doi:10.1186/1758-2946-2-3.  edit
  4. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100–7. PMID 21948594. doi:10.1093/nar/gkr777.  edit
  5. Winn, M.; Arendsen, D.; Dodge, P.; Dren, A.; Dunnigan, D.; Hallas, R.; Hwang, K.; Kyncl, J.; Lee, Y. H. (1976). "Drugs derived from cannabinoids. 5. Delta6a,10a-Tetrahydrocannabinol and heterocyclic analogs containing aromatic side chains". Journal of Medicinal Chemistry 19 (4): 461–471. PMID 817021. doi:10.1021/jm00226a003. 
  6. Guterman A, Somani P, Bachand RT. Clinical Pharmacology and Therapeutics 1979; 25:227.
  7. Tiedeman, J. S.; Shields, M. B.; Weber, P. A.; Crow, J. W.; Cocchetto, D. M.; Harris, W. A.; Howes, J. F. (1981). "Effect of synthetic cannabinoids on elevated intraocular pressure". Ophthalmology 88 (3): 270–277. PMID 7015221. 

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