JTE-907

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JTE-907
(IUPAC) ime
N-(benzo[1,3]dioksol-5-ilmetil)-7-metoksi-2-okso-8-pentiloksi-1,2-dihidrohinolin-3-karboksamid
Klinički podaci
Identifikatori
CAS broj 282089-49-0
ATC kod nije dodeljen
PubChem[1][2] 9867770
Hemijski podaci
Formula C24H26N2O6 
Mol. masa 438,472
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća  ?
Pravni status

JTE-907 je lek koji se koristi u naučnim istraživanjima. On deluje kao selektivni inverzni agonist CB2 receptora.[3][4] On ima antiinflamatorno dejstvo u životinjskim studijama.[5] Smatra se da posreduje interakciju između CB2 receptora u IgE.[6]

Reference[uredi - уреди | uredi izvor]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Iwamura, H; Suzuki, H; Ueda, Y; Kaya, T; Inaba, T (2001). "In vitro and in vivo pharmacological characterization of JTE-907, a novel selective ligand for cannabinoid CB2 receptor". The Journal of Pharmacology and Experimental Therapeutics 296 (2): 420–5. PMID 11160626. 
  4. Raitio, KH; Savinainen, JR; Vepsäläinen, J; Laitinen, JT; Poso, A; Järvinen, T; Nevalainen, T (2006). "Synthesis and SAR studies of 2-oxoquinoline derivatives as CB2 receptor inverse agonists". Journal of Medical Chemistry 49 (6): 2022–7. PMID 16539390. doi:10.1021/jm050879z. 
  5. Ueda, Y; Miyagawa, N; Matsui, T; Kaya, T; Iwamura, H (2005). "Involvement of cannabinoid CB(2) receptor-mediated response and efficacy of cannabinoid CB(2) receptor inverse agonist, JTE-907, in cutaneous inflammation in mice". European Journal of Pharmacology 520 (1–3): 164–71. PMID 16153638. doi:10.1016/j.ejphar.2005.08.013. 
  6. Ueda, Y; Miyagawa, N; Wakitani, K (2007). "Involvement of cannabinoid CB2 receptors in the IgE-mediated triphasic cutaneous reaction in mice". Life Sciences 80 (5): 414–9. PMID 17055000. doi:10.1016/j.lfs.2006.09.026. 

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