Kanabinol
Izgled
![]() | |||
![]() | |||
(IUPAC) ime | |||
---|---|---|---|
6,6,9-trimetil-3-pentil-benzo[c]hromen-1-ol | |||
Klinički podaci | |||
Identifikatori | |||
CAS broj | 521-35-7 | ||
ATC kod | nije dodeljen | ||
PubChem[1][2] | 2543 | ||
ChemSpider[3] | 2447 | ||
UNII | 7UYP6MC9GH ![]() | ||
KEGG[4] | C07580 ![]() | ||
ChEMBL[5] | CHEMBL74415 ![]() | ||
Hemijski podaci | |||
Formula | C21H26O2 | ||
Mol. masa | 310,4319 g/mol | ||
SMILES | eMolekuli & PubHem | ||
| |||
Fizički podaci | |||
Tačka topljenja | 77 °C (171 °F) | ||
Rastvorljivost u voda | nerastvoran je u vodi,[6] rastvoran je u metanolu i etanolu[7] mg/mL (20 °C) | ||
Farmakoinformacioni podaci | |||
Trudnoća | ? | ||
Pravni status |
Kanabinol (CBN) je slab psihoaktivni kanabinoid prisutan u Cannabis sativa i Cannabis indica.[8] On je takođe metabolit tetrahidrokanabinola (THC).[9] CBN deluje kao slab agonist CB1 receptora. On ima visok afinitet za CB2 receptore, mada niži nego THC.[10][11]
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.
- ↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.
- ↑ Lide, David R. (2012). CRC Handbook of Chemistry and Physics. CRC Press. str. 3-90. ISBN 1-43988049-2.
- ↑ Biotrend: Cannabinol Arhivirano 2016-05-22 na Wayback Machine-u (PDF: 21 kB)
- ↑ Karniol IG, Shirakawa I, Takahashi RN, Knobel E, Musty RE (1975). „Effects of delta9-tetrahydrocannabinol and cannabinol in man”. Pharmacology 13 (6): 502–12. DOI:10.1159/000136944. PMID 1221432.
- ↑ McCallum ND, Yagen B, Levy S, Mechoulam R (May 1975). „Cannabinol: a rapidly formed metabolite of delta-1- and delta-6-tetrahydrocannabinol”. Experientia 31 (5): 520–1. PMID 1140243.
- ↑ Mahadevan A, Siegel C, Martin BR, Abood ME, Beletskaya I, Razdan RK (October 2000). „Novel cannabinol probes for CB1 and CB2 cannabinoid receptors”. Journal of Medicinal Chemistry 43 (20): 3778–85. DOI:10.1021/jm0001572. PMID 11020293.
- ↑ Petitet F, Jeantaud B, Reibaud M, Imperato A, Dubroeucq MC (1998). „Complex pharmacology of natural cannabinoids: evidence for partial agonist activity of delta9-tetrahydrocannabinol and antagonist activity of cannabidiol on rat brain cannabinoid receptors”. Life Sciences 63 (1): PL1–6. DOI:10.1016/S0024-3205(98)00238-0. PMID 9667767.
- Erowid Compounds found in Cannabis sativa