Kanabigerol

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Kanabigerol
(IUPAC) ime
2-[(2E)-3,7-dimetilokta-2,6-dienil]-5-pentil-benzen-1,3-diol
Klinički podaci
Identifikatori
CAS broj 25654-31-3
ATC kod nije dodeljen
PubChem[1][2] 5315659
ChemSpider[3] 4474921
ChEMBL[4] CHEMBL497318 YesY
Hemijski podaci
Formula C21H32O2 
Mol. masa 316,48 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća ?
Pravni status

Kanabigerol (CBG) je kanabinoid iz Cannabis roda biljki koji nije psihoaktivan. Kanabigerol je prisutan u visokim koncentracijama u industrijskoj konoplji.

Kanabigerol deluje sa visokim afinitetom kao agonist α2-adrenergičkog receptora, umereni antagonist 5-HT1A receptora, i slab antagonist CB1 receptora.[5] It also binds to the CB2 receptor, but whether it acts as an agonist or antagonist at this site is unknown.[5]

Reference[uredi - уреди | uredi izvor]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. PMID 20331846. doi:10.1186/1758-2946-2-3.  edit
  4. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100–7. PMID 21948594. doi:10.1093/nar/gkr777.  edit
  5. 5,0 5,1 Cascio MG, Gauson LA, Stevenson LA, Ross RA, Pertwee R (December 2009). "Evidence that the plant cannabinoid cannabigerol is a highly potent alpha(2)-adrenoceptor agonist and moderately potent 5HT receptor antagonist". British Journal of Pharmacology 159 (1): 129–141. PMC 2823359. PMID 20002104. doi:10.1111/j.1476-5381.2009.00515.x. 

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