Kanbisol

Kanbisol
(IUPAC) ime
	(6aR,9R,10aR)-6,6-dimetil-3-(2-metiloktan-2-il)-6a,7,8,9,10,10a-heksahidrobenzo[c]hromen-1,9-diol
Klinički podaci
Identifikatori
CAS broj	56689-43-1
ATC kod	nije dodeljen
PubChem	41969
ChemSpider	16736847
UNII	NZ1ZPC4WSF
Hemijski podaci
Formula	C24H38O3
Mol. masa	374,555 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C24H38O3/c1-6-7-8-9-12-23(2,3)16-13-20(26)22-18-15-17(25)10-11-19(18)24(4,5)27-21(22)14-16/h13-14,17-19,25-26H,6-12,15H2,1-5H3/t17?,18-,19-/m0/s1 ; Key: UEKGZFCGRQYMRM-MNNMKWMVSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

Kanbisol (Nabidroks), je sintetički kanabinoidni derivat koji je dimetilheptilni homolog 9-nor-9β-hidroksiheksahidrokanabinola (HHC). On je potentan agonist CB₁ i CB₂ receptora, sa afinitetom vezivanja od 0,1 nM na CB₁ i 0,2 nM na CB₂.^[4] On prvenstveno nalazi primenu u naučnim istraživanjima, u studijama receptorskog vezivanja s ciljem određivanja strukture i funkcije kanabinoidnih receptora.^[5]^[6]^[7] U pojedinim zemljama je kontrolisana supstanca zbog njegove potencijalne zloupotrebe kao kanabinomimetski lek.^[8]

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Reference[uredi | uredi kod]

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Rhee MH, et al. (September 1997). „Cannabinol derivatives: binding to cannabinoid receptors and inhibition of adenylylcyclase”. Journal of Medicinal Chemistry 40 (20): 3228–33. DOI:10.1021/jm970126f. PMID 9379442.
↑ Rhee MH, et al. (December 2000). „Functional role of tryptophan residues in the fourth transmembrane domain of the CB(2) cannabinoid receptor”. Journal of Neurochemistry 75 (6): 2485–91. PMID 11080201.
↑ Rhee MH (September 2002). „Functional role of serine residues of transmembrane dopamin VII in signal transduction of CB2 cannabinoid receptor”. Journal of Veterinary Science 3 (3): 185–91. PMID 12514330.
↑ Zhang R, et al. (July 2005). „Cysteine 2.59(89) in the second transmembrane domain of human CB2 receptor is accessible within the ligand binding crevice: evidence for possible CB2 deviation from a rhodopsin template”. Molecular Pharmacology 68 (1): 69–83. DOI:10.1124/mol.104.007823. PMID 15840841.
↑ The Misuse of Drugs Act 1971 (Amendment) Order 2009

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[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[pmid9379442-4] Rhee MH, et al. (September 1997). „Cannabinol derivatives: binding to cannabinoid receptors and inhibition of adenylylcyclase”. Journal of Medicinal Chemistry 40 (20): 3228–33. DOI:10.1021/jm970126f. PMID 9379442.

[pmid11080201-5] Rhee MH, et al. (December 2000). „Functional role of tryptophan residues in the fourth transmembrane domain of the CB(2) cannabinoid receptor”. Journal of Neurochemistry 75 (6): 2485–91. PMID 11080201.

[pmid12514330-6] Rhee MH (September 2002). „Functional role of serine residues of transmembrane dopamin VII in signal transduction of CB2 cannabinoid receptor”. Journal of Veterinary Science 3 (3): 185–91. PMID 12514330.

[pmid15840841-7] Zhang R, et al. (July 2005). „Cysteine 2.59(89) in the second transmembrane domain of human CB2 receptor is accessible within the ligand binding crevice: evidence for possible CB2 deviation from a rhodopsin template”. Molecular Pharmacology 68 (1): 69–83. DOI:10.1124/mol.104.007823. PMID 15840841.

[8] The Misuse of Drugs Act 1971 (Amendment) Order 2009

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Kanbisol

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