Kanbisol

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Kanbisol
(IUPAC) ime
(6aR,9R,10aR)-6,6-dimetil-3-(2-metiloktan-2-il)-6a,7,8,9,10,10a-heksahidrobenzo[c]hromen-1,9-diol
Klinički podaci
Identifikatori
CAS broj 56689-43-1
ATC kod nije dodeljen
PubChem[1][2] 41969
ChemSpider[3] 16736847
UNII NZ1ZPC4WSF YesY
Hemijski podaci
Formula C24H38O3 
Mol. masa 374,555 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća ?
Pravni status

Kanbisol (Nabidroks), je sintetički kanabinoidni derivat koji je dimetilheptilni homolog 9-nor-9β-hidroksiheksahidrokanabinola (HHC). On je potentan agonist CB1 i CB2 receptora, sa afinitetom vezivanja od 0,1 nM na CB1 i 0,2 nM na CB2.[4] On prvenstveno nalazi primenu u naučnim istraživanjima, u studijama receptorskog vezivanja s ciljem određivanja strukture i funkcije kanabinoidnih receptora.[5][6][7] U pojedinim zemljama je kontrolisana supstanca zbog njegove potencijalne zloupotrebe kao kanabinomimetski lek.[8]

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Reference[uredi - уреди | uredi izvor]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. PMID 20331846. doi:10.1186/1758-2946-2-3.  edit
  4. Rhee MH et al. (September 1997). "Cannabinol derivatives: binding to cannabinoid receptors and inhibition of adenylylcyclase". Journal of Medicinal Chemistry 40 (20): 3228–33. PMID 9379442. doi:10.1021/jm970126f. 
  5. Rhee MH et al. (December 2000). "Functional role of tryptophan residues in the fourth transmembrane domain of the CB(2) cannabinoid receptor". Journal of Neurochemistry 75 (6): 2485–91. PMID 11080201. 
  6. Rhee MH (September 2002). "Functional role of serine residues of transmembrane dopamin VII in signal transduction of CB2 cannabinoid receptor". Journal of Veterinary Science 3 (3): 185–91. PMID 12514330. 
  7. Zhang R et al. (July 2005). "Cysteine 2.59(89) in the second transmembrane domain of human CB2 receptor is accessible within the ligand binding crevice: evidence for possible CB2 deviation from a rhodopsin template". Molecular Pharmacology 68 (1): 69–83. PMID 15840841. doi:10.1124/mol.104.007823. 
  8. The Misuse of Drugs Act 1971 (Amendment) Order 2009

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