O-806

Izvor: Wikipedia
O-806
(IUPAC) ime
(6aR)-3-(6-bromoheks-2-inil)-6,6,9-trimetil-6a,7,10,10a-tetrahidrobenzo[c]hromen-1-ol
Klinički podaci
Identifikatori
ATC kod nije dodeljen
PubChem[1][2] 10549140
ChemSpider[3] 26001356
Hemijski podaci
Formula C22H27BrO2 
Mol. masa 403,352 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća  ?
Pravni status

O-806 je lek koji je kanabinoidni derivat sa primenom u naučnim istraživanjima. On je mešoviti agonist/antagonist kanabinoidnog receptora CB1. Drugim rečima on deluje kao antagonist kad se dozira zajedno sa potentnijim CB1 agonistom, dok je slab parcijalni agonist u odsustvu drugog agonist.[4][5]

Reference[uredi - уреди]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.  edit
  4. (1999) "An investigation into the structural determinants of cannabinoid receptor ligand efficacy". British Journal of Pharmacology 126 (7): 1575–1584. DOI:10.1038/sj.bjp.0702469. PMID 10323589. 
  5. (1999) "Cannabinoid agonists and antagonists discriminated by receptor binding in rat cerebellum". British Journal of Pharmacology 128 (3): 684–688. DOI:10.1038/sj.bjp.0702806. PMID 10516649. 

Spoljašnje veze[uredi - уреди]