Iproklozid

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Iproklozid
(IUPAC) ime
2-(4-hlorofenoksi)-N'-izopropil-acetohidrazid
Klinički podaci
Identifikatori
CAS broj 3544-35-2
ATC kod N06AF06
PubChem[1][2] 19063
ChemSpider[3] 17998
UNII 1II9D6CB3J YesY
KEGG[4] D07338 YesY
ChEMBL[5] CHEMBL91238 YesY
Hemijski podaci
Formula C11H15ClN2O2 
Mol. masa 242,70 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća  ?
Pravni status Uncontrolled
Način primene Oralno

Iproklozid (Sursum, Sinderezin) je ireverzibilni i selektivni inhibitor monoaminske oksidaze (MAOI) iz hidrazinske hemijske klase koji je korišten kao antidepresiv, ali je njegova primena prekinuta.[6] Poznato je da ovaj lek može da uzrokuje hepatitis i bilo je najmanje tri smrtna slučaja uzrokovana njegovom upotrebom.[7][8]

Reference[uredi - уреди | uredi izvor]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. PMID 20331846. doi:10.1186/1758-2946-2-3.  edit
  4. Joanne Wixon, Douglas Kell (2000). "Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG". Yeast 17 (1): 48–55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. 
  5. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100–7. PMID 21948594. doi:10.1093/nar/gkr777.  edit
  6. Suerinck A, Suerinck E. (1966). "[Depressive states in a sanatorium milieu and monoamine oxidase inhibitors. (Therapeutic results by the combination of iproclozide and chlordiazepoxide). Apropos of 146 cases]". Journal de médecine de Lyon 47 (96): 573–586. PMID 5930723. 
  7. Pessayre D, de Saint-Louvent P, Degott C, Bernuau J, Rueff B, Benhamou JP. (1978). "Iproclozide fulminant hepatitis. Possible role of enzyme induction.". Gastroenterology. 75 (3): 492–496. PMID 680506. 
  8. Neil Kaplowitz, Laurie D. DeLeve (2003). Drug-induced liver disease. Informa Health Care. str. 455. ISBN 0-8247-0811-3, 9780824708115. 

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