Ipsapiron

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Ipsapiron
(IUPAC) ime
9,9-diokso-8-[4-(4-pirimidin-2-ilpiperazin-1-il)butil]-
6-thia-8-azabiciklo[4.3.0]nona-1,3,5-trien-7-on
Klinički podaci
Identifikatori
CAS broj 95847-70-4
ATC kod nije dodeljen
PubChem[1][2] 56971
ChemSpider[3] 51365
UNII 6J9B11MN0K YesY
ChEMBL[4] CHEMBL8412 YesY
Hemijski podaci
Formula C19H23N5O3S 
Mol. masa 401,484 g/mol
SMILES eMolekuli & PubHem
Farmakokinetički podaci
Poluvreme eliminacije 1,3-2,7 sata
Farmakoinformacioni podaci
Trudnoća  ?
Pravni status Nije kontrolisana supstanca
Način primene Oralno

Ipsapiron je selektivni parcijalni agonist 5-HT1A receptor iz piperazinske i azapironske hemijske klase.[5] On ima antidepresivno i anksiolitičko dejstvo.[5]

Reference[uredi - уреди | uredi izvor]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. PMID 20331846. doi:10.1186/1758-2946-2-3.  edit
  4. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100–7. PMID 21948594. doi:10.1093/nar/gkr777.  edit
  5. 5,0 5,1 Fanelli RJ, Schuurman T, Glaser T, Traber J (1990). "Ipsapirone: a novel anxiolytic and selective 5-HT1A receptor ligand". Progress in clinical and biological research 361: 461–7. PMID 1981264. 

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