Iproniazid

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Iproniazid
(IUPAC) ime
N'-izopropilizonikotinohidrazid
Klinički podaci
AHFS/Drugs.com Internacionalno ime leka
Identifikatori
CAS broj 54-92-2
ATC kod N06AF05
PubChem[1][2] 3748
DrugBank DB04818
ChemSpider[3] 3617
UNII D892HFI3XA DaY
KEGG[4] D02579 DaY
ChEMBL[5] CHEMBL92401 DaY
Hemijski podaci
Formula C9H13N3O 
Mol. masa 179,219
SMILES eMolekuli & PubHem
Farmakokinetički podaci
Bioraspoloživost ?
Metabolizam ?
Poluvreme eliminacije ?
Izlučivanje ?
Farmakoinformacioni podaci
Trudnoća ?
Pravni status ?
Način primene ?

Iproniazid (Eufozid, Iprazid, Ipronid, Ipronin, Marsilid, Rivivol) je hidrazinski lek koji je korišten kao antidepresiv.[6] On deluje kao ireverzibilni i neselektivni inhibitor monoaminske oksidaze (MAOI).[7]

Reference[uredi | uredi kod]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.  edit
  4. Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. 
  5. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.  edit
  6. Robert A. Maxwell, Shohreh B. Eckhardt (1990). Drug discovery. Humana Press. str. 143–154. ISBN 9780896031807. 
  7. Fagervall I, Ross SB (April 1986). „Inhibition of monoamine oxidase in monoaminergic neurones in the rat brain by irreversible inhibitors”. Biochemical pharmacology 35 (8): 1381–7. DOI:10.1016/0006-2952(86)90285-6. PMID 2870717. 

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