Iproniazid

Iz Wikipedije, slobodne enciklopedije
Iproniazid
(IUPAC) ime
N'-izopropilizonikotinohidrazid
Klinički podaci
AHFS/Drugs.com Internacionalno ime leka
Identifikatori
CAS broj 54-92-2
ATC kod N06AF05
PubChem[1][2] 3748
DrugBank DB04818
ChemSpider[3] 3617
UNII D892HFI3XA YesY
KEGG[4] D02579 YesY
ChEMBL[5] CHEMBL92401 YesY
Hemijski podaci
Formula C9H13N3O 
Mol. masa 179,219
SMILES eMolekuli & PubHem
Farmakokinetički podaci
Bioraspoloživost  ?
Metabolizam  ?
Poluvreme eliminacije  ?
Izlučivanje  ?
Farmakoinformacioni podaci
Trudnoća  ?
Pravni status  ?
Način primene  ?

Iproniazid (Eufozid, Iprazid, Ipronid, Ipronin, Marsilid, Rivivol) je hidrazinski lek koji je korišten kao antidepresiv.[6] On deluje kao ireverzibilni i neselektivni inhibitor monoaminske oksidaze (MAOI).[7]

Reference[uredi - уреди | uredi izvor]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. PMID 20331846. doi:10.1186/1758-2946-2-3.  edit
  4. Joanne Wixon, Douglas Kell (2000). "Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG". Yeast 17 (1): 48–55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. 
  5. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100–7. PMID 21948594. doi:10.1093/nar/gkr777.  edit
  6. Robert A. Maxwell, Shohreh B. Eckhardt (1990). Drug discovery. Humana Press. str. 143–154. ISBN 0-89603-180-2, 9780896031807. 
  7. Fagervall I, Ross SB (April 1986). "Inhibition of monoamine oxidase in monoaminergic neurones in the rat brain by irreversible inhibitors". Biochemical pharmacology 35 (8): 1381–7. PMID 2870717. doi:10.1016/0006-2952(86)90285-6. 

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