WAY-208,466

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WAY-208,466
(IUPAC) ime
N'-[(2Z)-4-(2,4-dihlorofenil)-3-(2-metilpropil)-1,3-tiazol-2(3H)-iliden]-2-(pirazin-2-iloksi)acetohidrazid
Klinički podaci
Identifikatori
ATC kod nije dodeljen
PubChem[1][2] 11820788
ChemSpider[3] 9995440
ChEMBL[4] CHEMBL571858
Hemijski podaci
Formula C19H19Cl2N5O2S 
Mol. masa 452,36 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća  ?
Pravni status

WAY-208,466 je potentan i visoko selektivan pun agonist 5-HT6 receptora.[5] On povišava GABA nivoe u cerebralnom korteksu, i ne izaziva razvoj tolerancije na lek pri hroničnoj upotrebi.[5] Ispitivanja na životinjama su pokazala da WAY-208,466 ima antidepresivno i anksiolitičko dejstvo kod glodara i da možda može da bude koristan u tretmanu opsesivno-kompulzivnog poremećaja.[5][6]

Reference[uredi - уреди | uredi izvor]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. doi:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. doi:10.1186/1758-2946-2-3. PMID 20331846.  edit
  4. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100–7. doi:10.1093/nar/gkr777. PMID 21948594.  edit
  5. 5,0 5,1 5,2 Schechter LE, Lin Q, Smith DL et al. (May 2008). "Neuropharmacological profile of novel and selective 5-HT6 receptor agonists: WAY-181187 and WAY-208466". Neuropsychopharmacology 33 (6): 1323–35. doi:10.1038/sj.npp.1301503. PMID 17625499. 
  6. Carr GV, Schechter LE, Lucki I (March 2010). "Antidepressant and anxiolytic effects of selective 5-HT(6) receptor agonists in rats". Psychopharmacology 213 (2–3): 499–507. doi:10.1007/s00213-010-1798-7. PMC 2910165. PMID 20217056. 

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