LY-293,284

LY-293,284
(IUPAC) ime
	(4R)-6-acetil-4-(di-n-propilamino)-1,3,4,5-tetrahidrobenz[c,d]indol
Klinički podaci
Identifikatori
CAS broj	141318-62-9
ATC kod	nije dodeljen
PubChem	132345
Hemijski podaci
Formula	C19H26N2O
Mol. masa	298,423 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C19H26N2O/c1-4-8-21(9-5-2)15-10-14-12-20-18-7-6-16(13(3)22)17(11-15)19(14)18/h6-7,12,15,20H,4-5,8-11H2,1-3H3/t15-/m0/s1 ; Key: CKYZLYQSDNLGPT-HNNXBMFYSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

LY-293,284 je istraživačka hemikalija. On deluje kao potentan i selektivan pun agonist 5-HT_1A receptora. On je izveden putem nekoliko strukturnih simplifikacija na ergolinu baziranih halucinogena, LSD^[3] On je selektivan za 5-HT_1A sa preko 1000x selektivnošću u odnosu na druge tipove serotoninskog receptora i druge ciljeve.^[4] On pokazuje anksiogene efekte u životinjskim studijama.^[5]

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Monte AP, Marona-Lewicka D, Lewis MM, Mailman RB, Wainscott DB, Nelson DL, Nichols DE (June 1998). „Substituted naphthofurans as hallucinogenic phenethylamine-ergoline hybrid molecules with unexpected muscarinic antagonist activity”. Journal of Medicinal Chemistry 41 (12): 2134–45. DOI:10.1021/jm980076u. PMID 9622555.
↑ Foreman MM, Fuller RW, Rasmussen K, Nelson DL, Calligaro DO, Zhang L, Barrett JE, Booher RN, Paget CJ, Flaugh ME (September 1994). „Pharmacological characterization of LY293284: A 5-HT1A receptor agonist with high potency and selectivity”. The Journal of Pharmacology and Experimental Therapeutics 270 (3): 1270–81. PMID 7523657.
↑ Cao BJ, Rodgers RJ (October 1998). „Comparative effects of novel 5-HT1A receptor ligands, LY293284, LY315712 and LY297996, on plus-maze anxiety in mice”. Psychopharmacology 139 (3): 185–94. DOI:10.1007/s002130050703. PMID 9784072.

Vanjske veze

	Portal Medicina
	Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[pmid9622555-3] Monte AP, Marona-Lewicka D, Lewis MM, Mailman RB, Wainscott DB, Nelson DL, Nichols DE (June 1998). „Substituted naphthofurans as hallucinogenic phenethylamine-ergoline hybrid molecules with unexpected muscarinic antagonist activity”. Journal of Medicinal Chemistry 41 (12): 2134–45. DOI:10.1021/jm980076u. PMID 9622555.

[pmid7523657-4] Foreman MM, Fuller RW, Rasmussen K, Nelson DL, Calligaro DO, Zhang L, Barrett JE, Booher RN, Paget CJ, Flaugh ME (September 1994). „Pharmacological characterization of LY293284: A 5-HT1A receptor agonist with high potency and selectivity”. The Journal of Pharmacology and Experimental Therapeutics 270 (3): 1270–81. PMID 7523657.

[pmid9784072-5] Cao BJ, Rodgers RJ (October 1998). „Comparative effects of novel 5-HT1A receptor ligands, LY293284, LY315712 and LY297996, on plus-maze anxiety in mice”. Psychopharmacology 139 (3): 185–94. DOI:10.1007/s002130050703. PMID 9784072.

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