LY-293,284

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LY-293,284
(IUPAC) ime
(4R)-6-acetil-4-(di-n-propilamino)-1,3,4,5-tetrahidrobenz[c,d]indol
Klinički podaci
Identifikatori
CAS broj 141318-62-9
ATC kod nije dodeljen
PubChem[1][2] 132345
Hemijski podaci
Formula C19H26N2O 
Mol. masa 298,423 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća ?
Pravni status

LY-293,284 je istraživačka hemikalija. On deluje kao potentan i selektivan pun agonist 5-HT1A receptora. On je izveden putem nekoliko strukturnih simplifikacija na ergolinu baziranih halucinogena, LSD[3] On je selektivan za 5-HT1A sa preko 1000x selektivnošću u odnosu na druge tipove serotoninskog receptora i druge ciljeve.[4] On pokazuje anksiogene efekte u životinjskim studijama.[5]

Reference[uredi - уреди | uredi izvor]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Monte AP, Marona-Lewicka D, Lewis MM, Mailman RB, Wainscott DB, Nelson DL, Nichols DE (June 1998). "Substituted naphthofurans as hallucinogenic phenethylamine-ergoline hybrid molecules with unexpected muscarinic antagonist activity". Journal of Medicinal Chemistry 41 (12): 2134–45. PMID 9622555. doi:10.1021/jm980076u. 
  4. Foreman MM, Fuller RW, Rasmussen K, Nelson DL, Calligaro DO, Zhang L, Barrett JE, Booher RN, Paget CJ, Flaugh ME (September 1994). "Pharmacological characterization of LY293284: A 5-HT1A receptor agonist with high potency and selectivity". The Journal of Pharmacology and Experimental Therapeutics 270 (3): 1270–81. PMID 7523657. 
  5. Cao BJ, Rodgers RJ (October 1998). "Comparative effects of novel 5-HT1A receptor ligands, LY293284, LY315712 and LY297996, on plus-maze anxiety in mice". Psychopharmacology 139 (3): 185–94. PMID 9784072. doi:10.1007/s002130050703. 

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