BW-723C86

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BW-723C86
(IUPAC) ime
5-((thiophen-2-yl)methoxy)-α-methyltryptamine
Klinički podaci
Identifikatori
CAS broj 160521-72-2
ATC kod ?
PubChem[1][2] 5311036
Hemijski podaci
Formula C16H18N2OS 
Mol. masa 286.391 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća ?
Pravni status

BW-723C86 je lek izveden iz triptamina koji deluje kao agonist 5-HT2B receptora. On pokazuje anksiolitičke efekte u životinjskim studijama,[3][4] a upotrebljavan je i za istraživanje funkcije 5-HT2B receptora u nizu drugih tkiva.[5][6][7]

Reference[uredi - уреди | uredi izvor]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Kennett, GA; Bright, F; Trail, B; Baxter, GS; Blackburn, TP (April 1996). "Effects of the 5-HT2B receptor agonist, BW 723C86, on three rat models of anxiety". British journal of pharmacology 117 (7): 1443–8. PMC 1909458. PMID 8730737. 
  4. Kennett, G; Trail, B; Bright, F (December 1998). "Anxiolytic-like actions of BW 723C86 in the rat Vogel conflict test are 5-HT2B receptor mediated". Neuropharmacology 37 (12): 1603. PMID 9886683. doi:10.1016/S0028-3908(98)00115-4. 
  5. Knowles, Ian D; Ramage, Andrew G (January 2000). "Evidence that activation of central 5-HT2Breceptors causes renal sympathoexcitation in anaesthetized rats". British Journal of Pharmacology 129 (1): 177. PMC 1621132. PMID 10694218. doi:10.1038/sj.bjp.0703011. 
  6. G�nther, Silke; Maroteaux, Luc; Schwarzacher, Stephan W. (August 2006). "Endogenous 5-HT2B receptor activation regulates neonatal respiratory activityin vitro". Journal of Neurobiology 66 (9): 949. PMID 16758492. doi:10.1002/neu.20253. 
  7. Ryan, B; Anwyl, R; Rowan, M (August 2008). "5-HT2 receptor-mediated reversal of the inhibition of hippocampal long-term potentiation by acute inescapable stress". Neuropharmacology 55 (2): 175. PMID 18538800. doi:10.1016/j.neuropharm.2008.05.006. 

Spoljašnje veze[uredi - уреди | uredi izvor]


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