S-14,671

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S-14,671
(IUPAC) ime
N-{2-[4-(7-metoksinaftalen-1-il)piperazin-1-il]etil}tiofen-2-karboksamid
Klinički podaci
Identifikatori
CAS broj 135722-27-9
ATC kod nije dodeljen
PubChem[1][2] 131907
ChemSpider[3] 116529
Hemijski podaci
Formula C22H25N3O2S 
Mol. masa 395,52 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća ?
Pravni status

S-14,671 je naftilpiperazinski derivat koji deluje kao agonist 5-HT1A receptora (pKi = 9.3) sa visokom efikasnošću i izuzetnom in vivo potencijom. On je isto tako antagonist 5-HT2A i 5-HT2C receptor (oba imaju pKi = 7.8).[4][5] On pokazuje samo nizak afinitet za 5-HT1B i 5-HT3 receptore.[5]

Reference[uredi - уреди | uredi izvor]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. PMID 20331846. doi:10.1186/1758-2946-2-3.  edit
  4. Millan MJ, Canton H, Rivet JM, Lejeune F, Laubie M, Lavielle G (October 1991). "S 14671: a novel naphthylpiperazine 5-HT1A agonist of high efficacy and exceptional in vivo potency". European Journal of Pharmacology 203 (2): 319–22. PMID 1839284. doi:10.1016/0014-2999(91)90734-8. 
  5. 5,0 5,1 Millan MJ, Rivet JM, Canton H et al. (August 1992). "S 14671: a naphtylpiperazine 5-hydroxytryptamine1A agonist of exceptional potency and high efficacy possessing antagonist activity at 5-hydroxytryptamine1C/2 receptors". The Journal of Pharmacology and Experimental Therapeutics 262 (2): 451–63. PMID 1323650. 

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