Adatanserin

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Adatanserin
(IUPAC) ime
N-[2-(4-pirimidin-2-ilpiperazin-1-il)etil]adamantan-1-karboksamid
Klinički podaci
Identifikatori
CAS broj 127266-56-2
ATC kod nije dodeljen
PubChem[1][2] 130918
ChemSpider[3] 115774
UNII W5U6WQM26H YesY
Hemijski podaci
Formula C21H31N5O 
Mol. masa 369,50 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća ?
Pravni status

Adatanserin (WY-50,324, SEB-324) je mešoviti 5-HT1A receptor parcijalni agonist i antagonist 5-HT2A i 5-HT2C receptora.[4][5][6] On je razvijan kao kao antidepresiv ali je razboj zaustavljen.[6][7]

Adantaserin poseduje neuroprotektivna svojstva protiv ishemijom indukovane glutamatergičke ekscitotoksičnosti. Taj efekat je posredovan blokadom 5-HT2A receptora.[8]

Vidi još[uredi - уреди | uredi izvor]

Reference[uredi - уреди | uredi izvor]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. PMID 20331846. doi:10.1186/1758-2946-2-3.  edit
  4. Singh A, Lucki I (April 1993). "Antidepressant-like activity of compounds with varying efficacy at 5-HT1A receptors". Neuropharmacology 32 (4): 331–40. PMID 8497336. doi:10.1016/0028-3908(93)90153-T. 
  5. Kleven MS, Koek W (February 1996). "Pharmacological characterization of in vivo properties of putative mixed 5-HT1A agonist/5-HT2A/2C antagonist anxiolytics. I. Antipunishment effects in the pigeon". The Journal of Pharmacology and Experimental Therapeutics 276 (2): 388–97. PMID 8632301. 
  6. 6,0 6,1 Abou-Gharbia MA, Childers WE, Fletcher H et al. (December 1999). "Synthesis and SAR of adatanserin: novel adamantyl aryl- and heteroarylpiperazines with dual serotonin 5-HT(1A) and 5-HT(2) activity as potential anxiolytic and antidepressant agents". Journal of Medicinal Chemistry 42 (25): 5077–94. PMID 10602693. doi:10.1021/jm9806704. 
  7. Stahl, S. M. (2000). Essential psychopharmacology: neuroscientific basis and practical application. Cambridge, UK: Cambridge University Press. ISBN 0-521-64615-4. http://books.google.com/books?id=ICztBCFFRqEC&lpg=PA262&dq=adatanserin&as_brr=3&pg=PA262#v=onepage&q=adatanserin&f=false. 
  8. Dawson LA, Galandak J, Djali S (March 2002). "Attenuation of ischemic efflux of endogenous amino acids by the novel 5-HT(1A)/5-HT(2) receptor ligand adatanserin". Neurochemistry International 40 (3): 203–9. PMID 11741003. doi:10.1016/S0197-0186(01)00082-1. 

Literatura[uredi - уреди | uredi izvor]