Deramciklan

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Deramciklan
(IUPAC) ime
N,N-dimetil-2-([(1R,4R,6S)-1,7,7-trimetil-6-fenil-6-biciklo[2.2.1]heptanil]oksi)etanamin
Klinički podaci
Identifikatori
CAS broj 120444-72-6
ATC kod nije dodeljen
PubChem[1][2] 119590
UNII O5KFK61E74 DaY
Hemijski podaci
Formula C20H31NO 
Mol. masa 301,466 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća ?
Pravni status

Deramciklan (EGIS-3886) je lek koji deluje kao antagonist na 5-HT2A receptoru,[3] kao inverzni agonist na 5-HT2C receptoru,[4] i kao inhibitor GABA preuzimanja.[5]

Reference[uredi | uredi kod]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. Kanerva, H.; Vilkman, H.; Någren, K.; Kilkku, O.; Kuoppamäki, M.; Syvälahti, E.; Hietala, J. (1999). „Brain 5-HT2A receptor occupancy of deramciclane in humans after a single oral administration--a positron emission tomography study”. Psychopharmacology 145 (1): 76–81. DOI:10.1007/s002130051034. PMID 10445375. 
  4. Pälvimäki, E. P.; Majasuo, H.; Kuoppamäki, M.; Männistö, P. T.; Syvälahti, E.; Hietala, J. (1998). „Deramciclane, a putative anxiolytic drug, is a serotonin 5-HT2C receptor inverse agonist but fails to induce 5-HT2C receptor down-regulation”. Psychopharmacology 136 (2): 99–104. DOI:10.1007/s002130050544. PMID 9551765. 
  5. Kovács, I.; Maksay, G.; Simonyi, M. (1989). „Inhibition of high-affinity synaptosomal uptake of gamma-aminobutyric acid by a bicyclo-heptane derivative”. Arzneimittel-Forschung 39 (3): 295–297. PMID 2502985. 

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