Lezogaberan
Izgled
(Preusmjereno sa stranice Lesogaberan)
Lezogaberan | |||
---|---|---|---|
IUPAC ime |
| ||
Drugi nazivi | AZD-3355 | ||
Identifikacija | |||
CAS registarski broj | 344413-67-8 | ||
PubChem[1][2] | 9833984 | ||
UNII | 4D6Q6HGC7Z | ||
ChEMBL[3] | CHEMBL448343 | ||
Jmol-3D slike | Slika 1 | ||
| |||
Svojstva | |||
Molekulska formula | C3H9FNO2P | ||
Molarna masa | 141.08 g mol−1 | ||
Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala | |||
Infobox references |
Lezogaberan (AZD-3355) je[4] eksperimentalni lek za tretiranje gastroesofagealna refluksne bolesti.[5] On je agonist GABAB receptora,[6] i ima isti mehanizam dejstva kao i baklofen, ali se očekuje da će imati manje nuspojava vezanih za centralni nervni sistem, koje ograničavaju kliničku primenu baklofena.[7]
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.
- ↑ AstraZeneca. „AZD3355”. Arhivirano iz originala na datum 2012-04-26. Pristupljeno 30. 12. 2011.
- ↑ Bredenoord, Albert J. (2009). „Lesogaberan, a GABAB agonist for the potential treatment of gastroesophageal reflux disease”. IDrugs 12 (9): 576–584. PMID 19697277.
- ↑ Alstermark, et al.; Amin, K; Dinn, SR; Elebring, T; Fjellström, O; Fitzpatrick, K; Geiss, WB; Gottfries, J i dr.. (2008). „Synthesis and Pharmacological Evaluation of Novel γ-Aminobutyric Acid Type B (GABAB) Receptor Agonists as Gastroesophageal Reflux Inhibitors”. Journal of Medicinal Chemistry 51 (14): 4315–4320. DOI:10.1021/jm701425k. PMID 18578471.
- ↑ Brian E. Lacy, Robert Chehade, and Michael D. Crowell (2010). „Lesogaberan”. Drugs of the Future 35 (12): 987–992. DOI:10.1358/dof.2010.035.012.1540661.