Furosemid

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Furosemid
(IUPAC) ime
4-hloro-2-(furan-2-ilmetilamino)- 5-sulfamoilbenzojeva kiselina
Klinički podaci
Identifikatori
CAS broj 54-31-9
ATC kod C03CA01
PubChem[1][2] 3440
DrugBank DB00695
ChemSpider[3] 3322
UNII 7LXU5N7ZO5 YesY
KEGG[4] D00331 YesY
ChEBI CHEBI:47426 YesY
ChEMBL[5] CHEMBL35 YesY
Hemijski podaci
Formula C12H11ClN2O5S 
Mol. masa 330,745 g/mol
SMILES eMolekuli & PubHem
Farmakokinetički podaci
Bioraspoloživost 43-69%
Metabolizam hepatički i renalna glukuronidacija
Poluvreme eliminacije do 100 minuta
Izlučivanje renalno 66%, bilijarno 33%
Farmakoinformacioni podaci
Licenca

US Daily Med:link

Trudnoća C(AU) C(US)
Pravni status Prescription only
Način primene Oralno, IV, IM

Furosemid[6] ili frusemid je diuretik Henleove petlje koji se koristi u tretmanu kongestivnog zatajenja srca i edema. Ovaj lek proizvodi i prodaje preduzeće Sanofi pod imenom Lasix. On je takođe dostupan pod imenima Fusid i Frumex.[7]

Reference[uredi - уреди | uredi izvor]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. PMID 20331846. doi:10.1186/1758-2946-2-3.  edit
  4. Joanne Wixon, Douglas Kell (2000). "Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG". Yeast 17 (1): 48–55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. 
  5. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100–7. PMID 21948594. doi:10.1093/nar/gkr777.  edit
  6. Changes to medicines names: BANs to rINNs
  7. Frumex

Literatura[uredi - уреди | uredi izvor]

  • Aventis Pharma (1998). Lasix Approved Product Information. Lane Cove: Aventis Pharma Pty Ltd.
  • Barbara Forney (2007). Understanding Equine Medications, Revised Edition (Horse Health Care Library). Eclipse Press. ISBN 1-58150-151-X. 

Spoljašnje veze[uredi - уреди | uredi izvor]

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