Furosemid

Furosemid
(IUPAC) ime
	4-hloro-2-(furan-2-ilmetilamino)- 5-sulfamoilbenzojeva kiselina
Klinički podaci
Identifikatori
CAS broj	54-31-9
ATC kod	C03CA01
PubChem	3440
DrugBank	DB00695
ChemSpider	3322
UNII	7LXU5N7ZO5
KEGG	D00331
ChEBI	CHEBI:47426
ChEMBL	CHEMBL35
Hemijski podaci
Formula	C12H11ClN2O5S
Mol. masa	330,745 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C12H11ClN2O5S/c13-9-5-10(15-6-7-2-1-3-20-7)8(12(16)17)4-11(9)21(14,18)19/h1-5,15H,6H2,(H,16,17)(H2,14,18,19) ; Key: ZZUFCTLCJUWOSV-UHFFFAOYSA-N
Farmakokinetički podaci
Bioraspoloživost	43-69%
Metabolizam	hepatički i renalna glukuronidacija
Poluvreme eliminacije	do 100 minuta
Izlučivanje	renalno 66%, bilijarno 33%
Farmakoinformacioni podaci
Licenca	US Daily Med:link
Trudnoća	C(AU) C(US)
Pravni status	℞ Prescription only
Način primene	Oralno, IV, IM

Furosemid^[6] ili frusemid je diuretik Henleove petlje koji se koristi u tretmanu kongestivnog zatajenja srca i edema. Ovaj lek proizvodi i prodaje preduzeće Sanofi pod imenom Lasix. On je takođe dostupan pod imenima Fusid i Frumex.^[7]

Reference[uredi | uredi kod]

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Changes to medicines names: BANs to rINNs
↑ Frumex

Aventis Pharma (1998). Lasix Approved Product Information. Lane Cove: Aventis Pharma Pty Ltd.
Barbara Forney (2007). Understanding Equine Medications, Revised Edition (Horse Health Care Library). Eclipse Press. ISBN 1-58150-151-X.

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