Temazepam

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Temazepam
(IUPAC) ime
7-hloro-1,3-dihidro-3-hidroksi-1-metil-5-fenil-1,4-benzodiazepin-2-on
Klinički podaci
Robne marke Restoril
AHFS/Drugs.com Monografija
MedlinePlus a684003
Identifikatori
CAS broj 846-50-4
ATC kod N05CD07
PubChem[1][2] 5391
DrugBank DB00231
ChemSpider[3] 5198
UNII CHB1QD2QSS YesY
KEGG[4] D00370 YesY
ChEMBL[5] CHEMBL967 YesY
Hemijski podaci
Formula C16H13ClN2O2 
Mol. masa 300,7 g/mol
SMILES eMolekuli & PubHem
Farmakokinetički podaci
Bioraspoloživost 96%
Metabolizam Hepatički
Poluvreme eliminacije 8–20 sata
Izlučivanje Renalno
Farmakoinformacioni podaci
Trudnoća C(AU) X(US)
Pravni status Samo na recept (S4) (AU) Schedule IV (CA) POM (UK) Schedule IV (SAD)
Način primene Oralno

Temazepam (Restoril - 15 mg/30 mg i Normison) hipnotik je srednje brzine dejstva. On je 3-hidroksi derivat iz benzodiazepinske klase psihoaktivnih lekova. Temazepam je odobren za kratkotrajne tretmane insomnije. Pored toga, temazepam ima anksiolitička, antikonvulsivna, i miorelaksantna svojstva.[6][7][8]

Reference[uredi - уреди | uredi izvor]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. PMID 20331846. doi:10.1186/1758-2946-2-3.  edit
  4. Joanne Wixon, Douglas Kell (2000). "Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG". Yeast 17 (1): 48–55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. 
  5. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100–7. PMID 21948594. doi:10.1093/nar/gkr777.  edit
  6. Wynn RL; McFarland SA, Meyer EA, Coffman WB, Mumford R (1980). "Structure activity relationships of selected benzodiazepines as anticonvulsants to local anesthetics". Pharmacol Ther Dent 5 (1-2): 39–45. PMID 6774348. 
  7. Siciliani O; Schiavon M, Tansella M (August 1975). "Anxiety and EEG alpha activity in neurotic patients". Acta Psychiatr Scand 52 (2): 116–31. PMID 1096540. doi:10.1111/j.1600-0447.1975.tb00028.x. 
  8. Fuccella LM (1979). "Bioavailability of temazepam in soft gelatin capsules" (PDF). Br J Clin Pharmacol 8 (1): 31S–5S. PMC 1429631. PMID 41540. 

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