Temazepam

Temazepam
(IUPAC) ime
	7-hloro-1,3-dihidro-3-hidroksi-1-metil-5-fenil-1,4-benzodiazepin-2-on
Klinički podaci
Robne marke	Restoril
AHFS/Drugs.com	Monografija
MedlinePlus	a684003
Identifikatori
CAS broj	846-50-4
ATC kod	N05CD07
PubChem	5391
DrugBank	DB00231
ChemSpider	5198
UNII	CHB1QD2QSS
KEGG	D00370
ChEMBL	CHEMBL967
Hemijski podaci
Formula	C16H13ClN2O2
Mol. masa	300,7 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C16H13ClN2O2/c1-19-13-8-7-11(17)9-12(13)14(18-15(20)16(19)21)10-5-3-2-4-6-10/h2-9,15,20H,1H3 ; Key: SEQDDYPDSLOBDC-UHFFFAOYSA-N
Farmakokinetički podaci
Bioraspoloživost	96%
Metabolizam	Hepatički
Poluvreme eliminacije	8–20 sata
Izlučivanje	Renalno
Farmakoinformacioni podaci
Trudnoća	C(AU) X(US)
Pravni status	Samo na recept (S4) (AU) Schedule IV (CA) POM (UK) Schedule IV (SAD)
Način primene	Oralno

Temazepam (Restoril - 15 mg/30 mg i Normison) hipnotik je srednje brzine dejstva. On je 3-hidroksi derivat iz benzodiazepinske klase psihoaktivnih lekova. Temazepam je odobren za kratkotrajne tretmane insomnije. Pored toga, temazepam ima anksiolitička, antikonvulsivna, i miorelaksantna svojstva.^[6]^[7]^[8]

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Wynn RL; McFarland SA, Meyer EA, Coffman WB, Mumford R (1980). „Structure activity relationships of selected benzodiazepines as anticonvulsants to local anesthetics”. Pharmacol Ther Dent 5 (1-2): 39–45. PMID 6774348.
↑ Siciliani O; Schiavon M, Tansella M (August 1975). „Anxiety and EEG alpha activity in neurotic patients”. Acta Psychiatr Scand 52 (2): 116–31. DOI:10.1111/j.1600-0447.1975.tb00028.x. PMID 1096540.
↑ Fuccella LM (1979). „Bioavailability of temazepam in soft gelatin capsules” (PDF). Br J Clin Pharmacol 8 (1): 31S–5S. PMC 1429631. PMID 41540.

Povezano

Spoljašnje veze

	Portal Medicina
	Portal Hemija

Temazepam | Rx-List Arhivirano 2008-09-12 na Wayback Machine-u
Temazepam | Inchem
Temazepam | Medline Plus
Active Ingredients information | DrugLib Arhivirano 2012-11-01 na Wayback Machine-u
Benzodiazepine Addiction, Withdrawal & Recovery | benzo.org.uk

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[5] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[6] Wynn RL; McFarland SA, Meyer EA, Coffman WB, Mumford R (1980). „Structure activity relationships of selected benzodiazepines as anticonvulsants to local anesthetics”. Pharmacol Ther Dent 5 (1-2): 39–45. PMID 6774348.

[7] Siciliani O; Schiavon M, Tansella M (August 1975). „Anxiety and EEG alpha activity in neurotic patients”. Acta Psychiatr Scand 52 (2): 116–31. DOI:10.1111/j.1600-0447.1975.tb00028.x. PMID 1096540.

[8] Fuccella LM (1979). „Bioavailability of temazepam in soft gelatin capsules” (PDF). Br J Clin Pharmacol 8 (1): 31S–5S. PMC 1429631. PMID 41540.

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