Lorazepam

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Lorazepam
(IUPAC) ime
7-hloro-5-(2-hlorofenil)-3-hidroksi-2,3-dihidro-1H-1,4-benzodiazepin-2-on
Klinički podaci
Robne marke Almazine, Alzapam, Anxiedin, Aplacassee
AHFS/Drugs.com Monografija
Identifikatori
CAS broj 846-49-1
ATC kod N05BA06
PubChem[1][2] 3958
DrugBank DB00186
ChemSpider[3] 3821
Hemijski podaci
Formula C15H10Cl2N2O2 
Mol. masa 321.158
SMILES eMolekuli & PubHem
Fizički podaci
Tačka topljenja 167 °C (333 °F)
Farmakokinetički podaci
Poluvreme eliminacije 14±5 sati (Parenteralno)
Izlučivanje 88% urinom
Farmakoinformacioni podaci
Trudnoća ?
Pravni status
Način primene Parenteralno; Oralno

Lorazepam je benzodiazepin koji se koristi kao agens protiv anksioznosti sa malim brojem nuspojava. On takođe ima hipnotička, antikonvulsivna, u znatna sedativna svojstva.[4][5][6][7][8][9][10] Trgovačka imena: Lorazepam (Hemofarm a.d.), Lorsilan (Belupo).

Reference[uredi | uredi kod]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.  edit
  4. Kemper N, Poser W, Poser S: [Benzodiazepine dependence: addiction potential of the benzodiazepines is greater than previously assumed (author's transl)] Dtsch Med Wochenschr. 1980 Dec 5;105(49):1707-12. PMID 7439058
  5. Lader M: Short-term versus long-term benzodiazepine therapy. Curr Med Res Opin. 1984;8 Suppl 4:120-6. PMID 6144459
  6. Maltais F, Laberge F, Laviolette M: A randomized, double-blind, placebo-controlled study of lorazepam as premedication for bronchoscopy. Chest. 1996 May;109(5):1195-8. PMID 8625666
  7. Heisterkamp DV, Cohen PJ: The effect of intravenous premedication with lorazepam (ativan), pentobarbitone or diazepam on recall. Br J Anaesth. 1975 Jan;47(1):79-81. PMID 238548
  8. Milligan DW, Howard MR, Judd A: Premedication with lorazepam before bone marrow biopsy. J Clin Pathol. 1987 Jun;40(6):696-8. PMID 3611398
  9. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035-41. PMID 21059682. 
  10. Wishart DS, Knox C, Guo AC, Cheng D, Shrivastava S, Tzur D, Gautam B, Hassanali M (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Res 36 (Database issue): D901-6. PMID 18048412. 

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