Fenobarbital
(IUPAC ) ime
5-etil-5-phenil-1,3-diazinan-2,4,6-trion
Klinički podaci
Robne marke
Adonal, Aephenal, Agrypnal, Amylofene
AHFS/Drugs.com
Monografija
Identifikatori
CAS broj
50-06-6
ATC kod
N03 AA01 N03 AA02
PubChem [1] [2] 4763
DrugBank
DB01174
ChemSpider [3] 4599
KEGG [4] C07434 Y
ChEMBL [5] CHEMBL8069 Y
Hemijski podaci
Formula
C 12 H 12 N 2 O 3
Mol. masa
232.2353
SMILES
eMolekuli PubHem
InChI InChI=1S/C12H12N2O3/c1-2-12(8-6-4-3-5-7-8)9(15)13-11(17)14-10(12)16/h3-7H,2H2,1H3,(H2,13,14,15,16,17) Y
Fizički podaci
Tačka topljenja
174 °C (345 °F)
Farmakokinetički podaci
Poluvreme eliminacije
53 do 118 sati
Farmakoinformacioni podaci
Trudnoća
?
Pravni status
Način primene
Oralno; Intramaskularno; Oralno;
Fenobarbital je derivat barbituratne kiseline , koji deluje kao neselektivni depresant centralnog nervnog sistema . On promoviše vezivanje za inhibitorni tip receptora gama-aminobuterine kiseline , i moduliše protok hlorida kroz receptorske kanale. On snažno inhibira glutamatom indukovane depolarizacije.[6] [7] [8] [9] [10] [11] [12]
↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.” . Drug Discov Today 15 (23-24): 1052-7. DOI :10.1016/j.drudis.2010.10.003 . PMID 20970519 . edit ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4 : 217-241. DOI :10.1016/S1574-1400(08)00012-1 . ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining” . J Cheminform 2 (1): 3. DOI :10.1186/1758-2946-2-3 . PMID 20331846 . edit ↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG” . Yeast 17 (1): 48–55. DOI :10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H . ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI :10.1093/nar/gkr777 . PMID 21948594 . edit ↑ Kwan P, Brodie MJ: Phenobarbital for the treatment of epilepsy in the 21st century: a critical review. Epilepsia. 2004 Sep;45(9):1141-9. PMID 15329080
↑ Taylor S, Tudur Smith C, Williamson PR, Marson AG: Phenobarbitone versus phenytoin monotherapy for partial onset seizures and generalized onset tonic-clonic seizures. Cochrane Database Syst Rev. 2001;(4):CD002217. PMID 11687150
↑ Tudur Smith C, Marson AG, Williamson PR: Carbamazepine versus phenobarbitone monotherapy for epilepsy. Cochrane Database Syst Rev. 2003;(1):CD001904. PMID 12535420
↑ Kalviainen R, Eriksson K, Parviainen I: Refractory generalised convulsive status epilepticus : a guide to treatment. CNS Drugs. 2005;19(9):759-68. PMID 16142991
↑ Booth D, Evans DJ: Anticonvulsants for neonates with seizures. Cochrane Database Syst Rev. 2004 Oct 18;(4):CD004218. PMID 15495087
↑ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035-41. PMID 21059682 . ↑ Nucleic Acids Res (2008). DrugBank: a knowledgebase for drugs, drug actions and drug targets . 36 . pp. D901-6. PMID 18048412 .
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