Tiamilal

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Tiamilal
(IUPAC) ime
5-(pentan-2-il)-5-(prop-2-en-1-il)-2-fulfaniliden-1,3-diazinan-4,6-dion
Klinički podaci
Robne marke Surital, Thioseconal
AHFS/Drugs.com Monografija
Identifikatori
CAS broj 77-27-0
ATC kod nije dodeljen
PubChem[1][2] 3032285
DrugBank DB01154
ChemSpider[3] 2297298
KEGG[4] C07846 YesY
ChEMBL[5] CHEMBL9536 YesY
Hemijski podaci
Formula C12H18N2O2S 
Mol. masa 254.349
SMILES eMolekuli & PubHem
Fizički podaci
Tačka topljenja 132-133 °C (-75 °F)
Farmakokinetički podaci
Poluvreme eliminacije Poluvreme kod mačaka je 14,3 sata.
Farmakoinformacioni podaci
Trudnoća ?
Pravni status

Tiamilal je barbiturat koji se intravenozno administrira radi ostvarivanja kompletne anestezije u toku kratkih perioda, za indukciju opšte anestezije, i za indukciju hipnotičkog stanja.[6][7][8]

Reference[uredi - уреди | uredi izvor]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. PMID 20331846. doi:10.1186/1758-2946-2-3.  edit
  4. Joanne Wixon, Douglas Kell (2000). "Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG". Yeast 17 (1): 48–55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. 
  5. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100–7. PMID 21948594. doi:10.1093/nar/gkr777.  edit
  6. Martindale, The Extra Pharmacopoeia, 30th ed, p919
  7. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). "DrugBank 3.0: a comprehensive resource for omics research on drugs". Nucleic Acids Res. 39 (Database issue): D1035–41. PMID 21059682. 
  8. Nucleic Acids Res (2008). "DrugBank: a knowledgebase for drugs, drug actions and drug targets" 36 (Database issue). pp. D901–6. PMID 18048412. 

Spoljašnje veze[uredi - уреди | uredi izvor]

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