Deksmedetomidin

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Deksmedetomidin
(IUPAC) ime
(S)-4-[1-(2,3-dimetilfenil)etil]-3H-imidazol
Klinički podaci
Robne marke Precedex, Dexdor
AHFS/Drugs.com Monografija
Identifikatori
CAS broj 113775-47-6
ATC kod N05CM18
PubChem[1][2] 68602
DrugBank DB00633
ChemSpider[3] 4470605
UNII 67VB76HONO YesY
KEGG[4] D00514 YesY
ChEBI CHEBI:4466 YesY
ChEMBL[5] CHEMBL778 YesY
Hemijski podaci
Formula C13H16N2 
Mol. masa 200,28 g/mol
SMILES eMolekuli & PubHem
Farmakokinetički podaci
Vezivanje za proteine plazme 94%
Metabolizam Skoro potpuni hepatički metabolizam do neaktivnog metabolita
Poluvreme eliminacije 2 sata
Izlučivanje Urinarno
Farmakoinformacioni podaci
Trudnoća C(US)
Pravni status -only (SAD)
Način primene Intravenozna infuzija

Deksmedetomidin (Precedeks, Deksdor) je sedativ koji koristi za intezivnu negu i anesteziju. On je relativno neobičan po tome što omogućava sedaciju bez izazivanja respiratorne depresije. Poput klonidina, on je agonist α2-adrenergičkog receptora u mozgu.[6] On je S-enantiomer medetomidina,[7] koji se koristi u veterini.

Reference[uredi - уреди | uredi izvor]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. PMID 20331846. doi:10.1186/1758-2946-2-3.  edit
  4. Joanne Wixon, Douglas Kell (2000). "Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG". Yeast 17 (1): 48–55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. 
  5. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100–7. PMID 21948594. doi:10.1093/nar/gkr777.  edit
  6. Cormack JR, Orme RM, Costello TG (2005). "The role of alpha2-agonists in neurosurgery". Journal of Clinical Neuroscience 12 (4): 375–8. PMID 15925765. doi:10.1016/j.jocn.2004.06.008. 
  7. PubChem 5311068

Literatura[uredi - уреди | uredi izvor]

  • "Dosing Guidelines for Precedex". http://www.precedex.com/wp-content/uploads/2010/02/Dosing_Guide.pdf. pristupljeno 21. 11. 2010.. 
  • Jackson KC, Wang Z, Wohlt P, Fine PG (2006). "Dexmedetomidine a novel analgesic with palliative medicine potential". J Pain and Palliative Care Pharmacotherapy 20 (2): 23–7. PMID 16702133. doi:10.1080/J354v20n02_05. 
  • Menon DV, Wang Z, Fadel PJ, Arbique D, Leonard D, Li JL, Victor RG, Vongpatanasin W. (2007). "Central sympatholysis as a novel countermeasure for cocaine-induced sympathetic activation and vasoconstriction in humans". J Am Coll Cardiol 50 (7): 626–33. PMID 17692748. doi:10.1016/j.jacc.2007.03.060. 
  • O'Connor, M; Bucknall, T; Manias, E (2009). "Sedation Management in Australian and New Zealand Intensive Care Units: Doctors' and Nurses' Practices and Opinions". Am J Crit Care 19 (3): 285–95. PMID 19770414. doi:10.4037/ajcc2009541. 
  • Pandharipande, PP; Pun, BT; Herr, DL; Maze, M; Girard, TD; Miller, RR; Shintani, AK; Thompson, JL; Jackson, JC (2007). "Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial". JAMA 298 (22): 2644–53. PMID 18073360. doi:10.1001/jama.298.22.2644. 
  • Paris A, Tonner PH (2005). "Dexmedetomidine in anaesthesia". Current Opinion in Anaesthesiology 18 (4): 412–8. PMID 16534267. doi:10.1097/01.aco.0000174958.05383.d5. 
  • Riker RR, Shehabi Y, Bokesch PM, Ceraso D, Wisemandle W, Koura F, Whitten P, Margolis BD, Byrne DW, Ely EW, Rocha MG (2009). "Dexmedetomidine vs Midazolam for Sedation of Critically Ill Patients: A Randomized Trial". JAMA 301 (5): 489–99. PMID 19188334. doi:10.1001/jama.2009.56. 
  • Dasta JF, Kane-Gill SL, Pencina M et al. (2010). "A cost-minimization analysis of dexmedetomidine compared with midazolam for long-term sedation in the intensive care unit". Crit Care Med 38 (2): 497–503. PMID 19789442. 
  • Wunsch H. (2011). "Weighing the Costs and Benefits of a Sedative". JAMA 307 (11): 1195–1197. doi:10.1001/jama.2012.319. 

Spoljašnje veze[uredi - уреди | uredi izvor]


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