Talipeksol

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Talipeksol
(IUPAC) ime
6-alil-5,6,7,8-tetrahidro-4H-[1,3]tiazolo[4,5-d]azepin-2-amin
Klinički podaci
AHFS/Drugs.com Internacionalno ime leka
Identifikatori
ATC kod nije dodeljen
PubChem[1][2] 5374
UNII 7AM2J46Z1Y YesY
ChEMBL[3] CHEMBL1289023 YesY
Hemijski podaci
Formula C10H15N3S 
Mol. masa 209,31 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća  ?
Pravni status Prescription only
Način primene Oralno

Talipeksol (B-HT920) je dopaminski agonist sa mogućom primenom kao antiparkinsonski agens.[4] On takođe deluje kao agonist α1-adrenergičkog i α2-adrenergičkog receptora.[5]

Reference[uredi - уреди | uredi izvor]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100–7. PMID 21948594. doi:10.1093/nar/gkr777.  edit
  4. Kitamura Y, Kosaka T, Kakimura JI et al. (December 1998). "Protective effects of the antiparkinsonian drugs talipexole and pramipexole against 1-methyl-4-phenylpyridinium-induced apoptotic death in human neuroblastoma SH-SY5Y cells". Mol. Pharmacol. 54 (6): 1046–54. PMID 9855633. 
  5. Van der Laan JW (February 1987). "Dopaminergic and alpha 1-adrenergic properties of B-HT920 revealed in morphine-dependent rats". Pharmacology, Biochemistry, and Behavior 26 (2): 265–9. PMID 2883663. doi:10.1016/0091-3057(87)90116-X. 

Spoljašnje veze[uredi - уреди | uredi izvor]


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