Talipeksol

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Talipeksol
(IUPAC) ime
6-alil-5,6,7,8-tetrahidro-4H-[1,3]tiazolo[4,5-d]azepin-2-amin
Klinički podaci
AHFS/Drugs.com Internacionalno ime leka
Identifikatori
ATC kod nije dodeljen
PubChem[1][2] 5374
UNII 7AM2J46Z1Y YesY
ChEMBL[3] CHEMBL1289023 YesY
Hemijski podaci
Formula C10H15N3S 
Mol. masa 209,31 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća ?
Pravni status Prescription only
Način primene Oralno

Talipeksol (B-HT920) je dopaminski agonist sa mogućom primenom kao antiparkinsonski agens.[4] On takođe deluje kao agonist α1-adrenergičkog i α2-adrenergičkog receptora.[5]

Reference[uredi - уреди | uredi kôd]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. http://www.sciencedirect.com/science/article/pii/S1359644610007737.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.  edit
  4. Kitamura Y, Kosaka T, Kakimura JI, et al. (December 1998). „Protective effects of the antiparkinsonian drugs talipexole and pramipexole against 1-methyl-4-phenylpyridinium-induced apoptotic death in human neuroblastoma SH-SY5Y cells”. Mol. Pharmacol. 54 (6): 1046–54. PMID 9855633. http://molpharm.aspetjournals.org/cgi/pmidlookup?view=long&pmid=9855633. 
  5. Van der Laan JW (February 1987). „Dopaminergic and alpha 1-adrenergic properties of B-HT920 revealed in morphine-dependent rats”. Pharmacology, Biochemistry, and Behavior 26 (2): 265–9. DOI:10.1016/0091-3057(87)90116-X. PMID 2883663. 

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