Dipivefrin
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(IUPAC) ime | |||
---|---|---|---|
[2-(2,2-dimetilpropanoiloksi)-4- (1-hidroksi-2-metilamino-etil)- fenil] 2,2-dimetilpropanoat | |||
Klinički podaci | |||
AHFS/Drugs.com | Internacionalno ime leka | ||
MedlinePlus | a686005 | ||
Identifikatori | |||
CAS broj | 52365-63-6 | ||
ATC kod | S01EA02 | ||
PubChem[1][2] | 3105 | ||
DrugBank | DB00449 | ||
ChemSpider[3] | 2994 | ||
UNII | 8Q1PVL543G | ||
KEGG[4] | D02349 | ||
ChEBI | CHEBI:4646 | ||
ChEMBL[5] | CHEMBL1201262 | ||
Hemijski podaci | |||
Formula | C19H29NO5 | ||
Mol. masa | 351,437 g/mol | ||
SMILES | eMolekuli & PubHem | ||
| |||
Farmakoinformacioni podaci | |||
Trudnoća | B(US) | ||
Pravni status |
Dipivefrin je prolek epinefrina koji se koristi za tretiranje glaukoma. On je dostupan kao oftalmički rastvor. Dipivefrin uzrokuje vazokonstrikciju, smanjuje proizvodnju očne tečnosti, i redukuje intraočni pritisak. On se konvertuje u epinefrin nakon penetracije korneje.[6]
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.
- ↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.
- ↑ Paul Diggory, Wendy Franks (1996). „Medical treatment of glaucoma - a reappraisal of the risks”. British Journal of Ophthalmology 80: 85-89.