Fenilpropanolamin

Fenilpropanolamin
(IUPAC) ime
	2-amino-1-fenilpropan-1-ol
Klinički podaci
AHFS/Drugs.com	Multum, informacije za potrošače
Identifikatori
CAS broj	14838-15-4
ATC kod	R01BA01 QG04BX91
PubChem	10297
DrugBank	DB00397
ChemSpider	9875
UNII	33RU150WUN
KEGG	D08368
ChEMBL	CHEMBL136560
Hemijski podaci
Formula	C9H13NO
Mol. masa	151,206 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C9H13NO/c1-7 (10)9 (11)8-5-3-2-4-6-8/h2-7,9,11H,10H2,1H3/t7-,9-/m0/s1 ; Key: DLNKOYKMWOXYQA-CBAPKCEASA-N
Farmakokinetički podaci
Poluvreme eliminacije	2,1 do 3,4 sata
Farmakoinformacioni podaci
Trudnoća	?
Pravni status	? (UK) ℞-only
Način primene	Oralno

Fenilpropanolamin (PPA, Accutrim) je stereoizomer norefedrina i norpseudoefedrina. On je psihoaktivni lek iz fenetilaminske i amfetaminske hemijske klase koji se koristi kao stimulans, dekongestiv, i anoreksik.^[6] On se koristi kao lek na recepat, i kao preparat za kašalj i prehladu koji je dostupan na slobodno. U veterini, on se koristi za kontrolu urinarne inkontinencije kod pasa (Propalin i Proin).

U Sjedinjenim Državama, PPA više nije u prodaji jer je utvrđeno da povećava rizik od srčanog udara kod mladih žena. U nekoliko evropskih zemalja on je još uvek dostupan. U Kanadi je ovaj lek povučen sa tržišta 2001.^[7] U Indiji je zabranjena ljudska upotreba PPA-a 2011.^[8]

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Flavahan NA (April 2005). „Phenylpropanolamine constricts mouse and human blood vessels by preferentially activating alpha2-adrenoceptors”. J. Pharmacol. Exp. Ther. 313 (1): 432–9. DOI:10.1124/jpet.104.076653. PMID 15608085. Arhivirano iz originala na datum 2023-07-19. Pristupljeno 2013-04-17.
↑ „Advisories, Warnings and Recalls - 2001”. Health Canada. 7. 1. 2009.. Arhivirano iz originala na datum 2010-05-03. Pristupljeno 10. 1. 2011.
↑ „Central Drugs Standard Control Organization, Dte.GHS, Ministry of Health and Family Welfare, Government of India”. Arhivirano iz originala na datum 2013-10-13. Pristupljeno 2013-04-17.

Povezano

Vanjske veze

Phenylpropanolamine Information Page at www.FDA.gov
Doubt Is Their Product by David Michaels, Scientific American, June 2005

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[5] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[pmid15608085-6] Flavahan NA (April 2005). „Phenylpropanolamine constricts mouse and human blood vessels by preferentially activating alpha2-adrenoceptors”. J. Pharmacol. Exp. Ther. 313 (1): 432–9. DOI:10.1124/jpet.104.076653. PMID 15608085. Arhivirano iz originala na datum 2023-07-19. Pristupljeno 2013-04-17.

[7] „Advisories, Warnings and Recalls - 2001”. Health Canada. 7. 1. 2009.. Arhivirano iz originala na datum 2010-05-03. Pristupljeno 10. 1. 2011.

[8] „Central Drugs Standard Control Organization, Dte.GHS, Ministry of Health and Family Welfare, Government of India”. Arhivirano iz originala na datum 2013-10-13. Pristupljeno 2013-04-17.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]