Korinantin

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Korinantin
(IUPAC) ime
metil estar (16β,17α)-17-hidroksi-johimban-16-karboksilne
Klinički podaci
Identifikatori
CAS broj 483-10-3
ATC kod nije dodeljen
PubChem[1][2] 92766
ChemSpider[3] 83744
Hemijski podaci
Formula C21H26N2O3 
Mol. masa 354,44 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća ?
Pravni status Nije kontrolisan
Način primene Oralno

Korinantin (rauhimbin) je alkaloid prisutan u biljkama vrsta Rauvolfia i Pausinystalia (ranije poznatih kao Corynanthe).[4][5] On je jedan od dva dijastereoizomera johimbina, dok je drugi rauvolscin.[6][7] On je takođe srodan sa ajmalicinom.

Reference[uredi - уреди | uredi kôd]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. http://www.sciencedirect.com/science/article/pii/S1359644610007737.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. http://www.jcheminf.com/content/2/1/3.  edit
  4. PHILLIPS DD, CHADHA MS (September 1955). „The alkaloids of Rauwolfia serpentina Benth”. Journal of the American Pharmaceutical Association. American Pharmaceutical Association 44 (9): 553–67. PMID 13251932. 
  5. „Alkaloids from Rauvolfia canescens; Pharmaceutical Biology - 39(3):Pages 239-240 - Informa Healthcare”. http://informahealthcare.com/doi/abs/10.1076/phbi.39.3.239.5923. 
  6. Shepperson NB, Duval N, Massingham R, Langer SZ (November 1981). „Pre- and postsynaptic alpha adrenoceptor selectivity studies with yohimbine and its two diastereoisomers rauwolscine and corynanthine in the anesthetized dog”. The Journal of Pharmacology and Experimental Therapeutics 219 (2): 540–6. PMID 6270312. http://jpet.aspetjournals.org/cgi/pmidlookup?view=long&pmid=6270312. 
  7. Doxey JC, Lane AC, Roach AG, Virdee NK (February 1984). „Comparison of the alpha-adrenoceptor antagonist profiles of idazoxan (RX 781094), yohimbine, rauwolscine and corynanthine”. Naunyn-Schmiedeberg's Archives of Pharmacology 325 (2): 136–44. PMID 6144048. 

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