Korinantin

Korinantin
(IUPAC) ime
	metil estar (16β,17α)-17-hidroksi-johimban-16-karboksilne
Klinički podaci
Identifikatori
CAS broj	483-10-3
ATC kod	nije dodeljen
PubChem	92766
ChemSpider	83744
Hemijski podaci
Formula	C21H26N2O3
Mol. masa	354,44 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C21H26N2O3/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24/h2-5,12,15,17-19,22,24H,6-11H2,1H3/t12-,15-,17-,18-,19-/m0/s1 ; Key: BLGXFZZNTVWLAY-DKJBZYCGSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status	Nije kontrolisan
Način primene	Oralno

Korinantin (rauhimbin) je alkaloid prisutan u biljkama vrsta Rauvolfia i Pausinystalia (ranije poznatih kao Corynanthe).^[4]^[5] On je jedan od dva dijastereoizomera johimbina, dok je drugi rauvolscin.^[6]^[7] On je takođe srodan sa ajmalicinom.

Reference[uredi | uredi kod]

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ PHILLIPS DD, CHADHA MS (September 1955). „The alkaloids of Rauwolfia serpentina Benth”. Journal of the American Pharmaceutical Association. American Pharmaceutical Association 44 (9): 553–67. PMID 13251932.
↑ „Alkaloids from Rauvolfia canescens; Pharmaceutical Biology - 39(3):Pages 239-240 - Informa Healthcare”.
↑ Shepperson NB, Duval N, Massingham R, Langer SZ (November 1981). „Pre- and postsynaptic alpha adrenoceptor selectivity studies with yohimbine and its two diastereoisomers rauwolscine and corynanthine in the anesthetized dog”. The Journal of Pharmacology and Experimental Therapeutics 219 (2): 540–6. PMID 6270312.
↑ Doxey JC, Lane AC, Roach AG, Virdee NK (February 1984). „Comparison of the alpha-adrenoceptor antagonist profiles of idazoxan (RX 781094), yohimbine, rauwolscine and corynanthine”. Naunyn-Schmiedeberg's Archives of Pharmacology 325 (2): 136–44. PMID 6144048.

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[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[pmid13251932-4] PHILLIPS DD, CHADHA MS (September 1955). „The alkaloids of Rauwolfia serpentina Benth”. Journal of the American Pharmaceutical Association. American Pharmaceutical Association 44 (9): 553–67. PMID 13251932.

[urlAlkaloids_from_Rauvolfia_canescens;_Pharmaceutical_Biology_-_39(3):Pages_239-240_-_Informa_Healthcare-5] „Alkaloids from Rauvolfia canescens; Pharmaceutical Biology - 39(3):Pages 239-240 - Informa Healthcare”.

[pmid6270312-6] Shepperson NB, Duval N, Massingham R, Langer SZ (November 1981). „Pre- and postsynaptic alpha adrenoceptor selectivity studies with yohimbine and its two diastereoisomers rauwolscine and corynanthine in the anesthetized dog”. The Journal of Pharmacology and Experimental Therapeutics 219 (2): 540–6. PMID 6270312.

[pmid6144048-7] Doxey JC, Lane AC, Roach AG, Virdee NK (February 1984). „Comparison of the alpha-adrenoceptor antagonist profiles of idazoxan (RX 781094), yohimbine, rauwolscine and corynanthine”. Naunyn-Schmiedeberg's Archives of Pharmacology 325 (2): 136–44. PMID 6144048.

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Korinantin

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