Metipranolol

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Metipranolol
(IUPAC) ime
(RS)-4[-2-hidroksi-3-(izopropilamino)propil]oksi2,3,6-trimetilfenil acetat
Klinički podaci
Robne marke Optipranolol
AHFS/Drugs.com Mikromedeks, detaljne potrošačke informacije
MedlinePlus a601078
Identifikatori
CAS broj 22664-55-7
ATC kod S01ED04 C07BA68
PubChem[1][2] 31477
DrugBank DB01214
ChemSpider[3] 29193
UNII X39AL81KEB YesY
KEGG[4] D02374 YesY
ChEMBL[5] CHEMBL1291 YesY
Hemijski podaci
Formula C17H27NO4 
Mol. masa 309,401 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća  ?
Pravni status

Metipranolol (OptiPranolol, Betanol, Disorat, Trimepranol) je neselektivni beta blokator koji se koristi u obliku kapi za oči za tretiranje glaukoma. On se brzo metaboliše u desacetilmetipranolol.[6]

Reference[uredi - уреди | uredi izvor]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. PMID 20331846. doi:10.1186/1758-2946-2-3.  edit
  4. Joanne Wixon, Douglas Kell (2000). "Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG". Yeast 17 (1): 48–55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. 
  5. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100–7. PMID 21948594. doi:10.1093/nar/gkr777.  edit
  6. Maffei Facino, R.; Bertuletti, R.; Carini, M.; Tofanetti, O. (1980). "In vitro metabolism of methypranolol by rat liver". Analytical Chemistry Symposia Series 4 (6): 217–223. 

Spoljašnje veze[uredi - уреди | uredi izvor]


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