Timolol

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Timolol
(IUPAC) ime
(S)-1-(tert-butilamino)-3-[(4-morfolin-4-il-1,2,5-tiadiazol-3-il)oksi]propan-2-ol
Klinički podaci
Robne marke Timoptik
AHFS/Drugs.com Monografija
MedlinePlus a602022
Identifikatori
CAS broj 26839-75-8
ATC kod C07AA06
PubChem[1][2] 33624
DrugBank DB00373
ChemSpider[3] 31013
UNII 5JKY92S7BR YesY
KEGG[4] D08600 YesY
ChEBI CHEBI:9599 YesY
ChEMBL[5] CHEMBL499 YesY
Hemijski podaci
Formula C13H24N4O3S 
Mol. masa 316,421 g/mol
SMILES eMolekuli & PubHem
Farmakokinetički podaci
Bioraspoloživost 60%
Metabolizam Hepatički: 80%
Poluvreme eliminacije 2,5-5 sata
Izlučivanje Renalno
Farmakoinformacioni podaci
Trudnoća C(AU) C(US)
Pravni status Prescription only
Način primene Oralno, oftalmički

Timolol maleat je neselektivni blokator beta-adrenergičkog receptora.[6]

Upotreba[uredi - уреди | uredi izvor]

U oralnom obliku (Blokadren), on se koristi:

Hemijska sinteza[uredi - уреди | uredi izvor]

Timolol 2.png

Reference[uredi - уреди | uredi izvor]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. PMID 20331846. doi:10.1186/1758-2946-2-3.  edit
  4. Joanne Wixon, Douglas Kell (2000). "Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG". Yeast 17 (1): 48–55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. 
  5. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100–7. PMID 21948594. doi:10.1093/nar/gkr777.  edit
  6. Hardman JG, Limbird LE, Gilman AG. (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10 izd.). New York: McGraw-Hill. DOI:10.1036/0071422803. ISBN 0-07-135469-7. http://books.mcgraw-hill.com/medical/goodmanandgilman/. 
  7. Dawn A. Marcus; Philip A. Bain (27 February 2009). Effective Migraine Treatment in Pregnant and Lactating Women: A Practical Guide. シュプリンガー・ジャパン株式会社. str. 141–. ISBN 978-1-60327-438-8. http://books.google.com/books?id=Z5YWpjj89NEC&pg=PA141. pristupljeno 14 November 2010. 

Spoljašnje veze[uredi - уреди | uredi izvor]


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