Dobutamin

Dobutamin
(IUPAC) ime
	(RS)-4-(2[4-(4-hidroksifenil)butan-2-il]amino}etil)benzen-1,2-diol
Klinički podaci
AHFS/Drugs.com	Monografija
MedlinePlus	a682861
Identifikatori
CAS broj	34368-04-2
ATC kod	C01CA07
PubChem	36811
DrugBank	DB00841
ChemSpider	33786
UNII	0WR771DJXV
KEGG	D03879
ChEBI	CHEBI:4670
ChEMBL	CHEMBL926
Hemijski podaci
Formula	C18H23NO3
Mol. masa	301,38 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C18H23NO3/c1-13(2-3-14-4-7-16(20)8-5-14)19-11-10-15-6-9-17(21)18(22)12-15/h4-9,12-13,19-22H,2-3,10-11H2,1H3 ; Key: JRWZLRBJNMZMFE-UHFFFAOYSA-N
Sinonimi	Dobutrex, Inotrex
Farmakokinetički podaci
Poluvreme eliminacije	2 minuta
Farmakoinformacioni podaci
Trudnoća	?
Pravni status	℞ Prescription only
Način primene	Intravenozno

Dobutamin je simpatomimetik koji se koristi u tretmanu zatajenja srca i kardiogenog šoka. Njegov primarni mehanizam je direktna stimulacija β₁ receptora simpatičkog nervnog sistema. Ilaj Lili end kompani je razvila dobutamin. On je strukturni analog izoprenalina.^[6]

Hemija[uredi | uredi kod]

On se može sintetisati reakcijom 2-(3,4-dimetoksifenil)etanamina i 1-(4-metoksifenil)-3-butanona, gde se simultanom redukcijom formira imin. Metoksilna zaštitna grupa ovog intermedijara se uklanja bromovodonikom, te se formira dobutamin.^[7]^[8]

Reference[uredi | uredi kod]

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Tuttle RR, Mills J (January 1975). „Dobutamine: development of a new catecholamine to selectively increase cardiac contractility”. Circ Res 36 (1): 185–96. DOI:10.1161/01.RES.36.1.185. PMID 234805.
↑ R. R. Tuttle, J. Mills, DE 2317710 (1973)
↑ J. Mills, R. R. Tuttle, U.S. Patent 3.987.200 (1976)

Spoljašnje veze[uredi | uredi kod]

	Portal Medicina
	Portal Hemija

Molimo Vas, obratite pažnju na važno upozorenje u vezi tema o zdravlju (medicini).

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[5] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[6] Tuttle RR, Mills J (January 1975). „Dobutamine: development of a new catecholamine to selectively increase cardiac contractility”. Circ Res 36 (1): 185–96. DOI:10.1161/01.RES.36.1.185. PMID 234805.

[7] R. R. Tuttle, J. Mills, DE 2317710 (1973)

[8] J. Mills, R. R. Tuttle, U.S. Patent 3.987.200 (1976)

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Dobutamin

Hemija[uredi | uredi kod]

Reference[uredi | uredi kod]

Spoljašnje veze[uredi | uredi kod]

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