Karteolol

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Karteolol
(IUPAC) ime
(RS)-5-[3-(tert-butilamino)-2-hidroksipropoksi]-3,4-dihidrohinolin-2(1H)-on
Klinički podaci
Robne marke Ocupress
AHFS/Drugs.com Mikromedeks, detaljne potrošačke informacije
MedlinePlus a601078
Identifikatori
CAS broj 51781-06-7
ATC kod C07AA15 S01ED05
PubChem[1][2] 2583
DrugBank DB00521
ChemSpider[3] 2485
UNII 8NF31401XG YesY
KEGG[4] D07624 YesY
ChEBI CHEBI:3437 YesY
ChEMBL[5] CHEMBL839 YesY
Hemijski podaci
Formula C16H24N2O3 
Mol. masa 292,373 g/mol
SMILES eMolekuli & PubHem
Farmakokinetički podaci
Bioraspoloživost 85%
Metabolizam Hepatički, aktivan sa 8-hidrokarteololom
Poluvreme eliminacije 6–8 sati
Izlučivanje Renalno (50-70%)
Farmakoinformacioni podaci
Trudnoća C(US)
Pravni status Prescription only
Način primene Kapi za oči

Karteolol (Cartrol, Ocupress, Teoptic, Arteolol, Arteoptic, Calte, Cartéabak, Carteol, Cartéol, Cartrol, Elebloc, Endak, Glauteolol, Mikelan, Poenglaucol, Singlauc) je neselektivni beta blokator koji se koristi u tretmanu glaukoma.

Reference[uredi - уреди | uredi izvor]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. PMID 20331846. doi:10.1186/1758-2946-2-3.  edit
  4. Joanne Wixon, Douglas Kell (2000). "Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG". Yeast 17 (1): 48–55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. 
  5. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100–7. PMID 21948594. doi:10.1093/nar/gkr777.  edit

Literatura[uredi - уреди | uredi izvor]

  • El-Kamel A, Al-Dosari H, Al-Jenoobi F (2006). "Environmentally responsive ophthalmic gel formulation of carteolol hydrochloride.". Drug Deliv 13 (1): 55–9. PMID 16401594. doi:10.1080/10717540500309073. 
  • Kuwahara K, Oizumi N, Fujisawa S, Tanito M, Ohira A (2005). "Carteolol hydrochloride protects human corneal epithelial cells from UVB-induced damage in vitro.". Cornea 24 (2): 213–20. PMID 15725891. doi:10.1097/01.ico.0000141232.41343.9d. 
  • Trinquand C, Romanet J, Nordmann J, Allaire C (2003). "[Efficacy and safety of long-acting carteolol 1% once daily. A double-masked, randomized study]". J Fr Ophtalmol 26 (2): 131–6. PMID 12660585. 

Spoljašnje veze[uredi - уреди | uredi izvor]


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