Piribedil

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Piribedil
(IUPAC) ime
2-[4-(benzo[1,3]dioksol-5-ilmetil)piperazin-1-il]pirimidin
Klinički podaci
AHFS/Drugs.com Internacionalno ime leka
Identifikatori
CAS broj 3605-01-4
ATC kod N04BC08
PubChem[1][2] 4850
UNII DO22K1PRDJ YesY
KEGG[3] D07305 YesY
ChEMBL[4] CHEMBL1371770 YesY
Hemijski podaci
Formula C16H18N4O2 
Mol. masa 298,340 g/mol
SMILES eMolekuli & PubHem
Farmakokinetički podaci
Poluvreme eliminacije 1,7-6,9 sata
Izlučivanje Renalno (68%) i bilijarno (25%)
Farmakoinformacioni podaci
Trudnoća ?
Pravni status Prescription only
Način primene Oralno

Piribedil (Trivastal, Pronoran, Trastal, Trivastan) je antiparkinsonski agens derivat piperazina koji deluje kao agonist D2 i D3 receptora. On isto tako deluje kao antagonist α2-adrenergičkog receptora.[5][6]

Indikacije[uredi - уреди | uredi kôd]

Izvori[uredi - уреди | uredi kôd]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. http://www.sciencedirect.com/science/article/pii/S1359644610007737.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. http://onlinelibrary.wiley.com/doi/10.1002/%28SICI%291097-0061%28200004%2917:1%3C48::AID-YEA2%3E3.0.CO;2-H/full. 
  4. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.  edit
  5. Millan MJ, Cussac D, Milligan G, et al. (June 2001). „Antiparkinsonian agent piribedil displays antagonist properties at native, rat, and cloned, human alpha(2)-adrenoceptors: cellular and functional characterization”. The Journal of Pharmacology and Experimental Therapeutics 297 (3): 876–87. PMID 11356907. http://jpet.aspetjournals.org/cgi/pmidlookup?view=long&pmid=11356907. 
  6. Gobert A, Di Cara B, Cistarelli L, Millan MJ (April 2003). „Piribedil enhances frontocortical and hippocampal release of acetylcholine in freely moving rats by blockade of alpha 2A-adrenoceptors: a dialysis comparison to talipexole and quinelorane in the absence of acetylcholinesterase inhibitors”. The Journal of Pharmacology and Experimental Therapeutics 305 (1): 338–46. DOI:10.1124/jpet.102.046383. PMID 12649387. http://jpet.aspetjournals.org/cgi/pmidlookup?view=long&pmid=12649387. 

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