Piribedil

Izvor: Wikipedija
Prijeđi na navigaciju Prijeđi na pretragu
Piribedil
(IUPAC) ime
2-[4-(benzo[1,3]dioksol-5-ilmetil)piperazin-1-il]pirimidin
Klinički podaci
AHFS/Drugs.com Internacionalno ime leka
Identifikatori
CAS broj 3605-01-4
ATC kod N04BC08
PubChem[1][2] 4850
UNII DO22K1PRDJ DaY
KEGG[3] D07305 DaY
ChEMBL[4] CHEMBL1371770 DaY
Hemijski podaci
Formula C16H18N4O2 
Mol. masa 298,340 g/mol
SMILES eMolekuli & PubHem
Farmakokinetički podaci
Poluvreme eliminacije 1,7-6,9 sata
Izlučivanje Renalno (68%) i bilijarno (25%)
Farmakoinformacioni podaci
Trudnoća ?
Pravni status Prescription only
Način primene Oralno

Piribedil (Trivastal, Pronoran, Trastal, Trivastan) je antiparkinsonski agens derivat piperazina koji deluje kao agonist D2 i D3 receptora. On isto tako deluje kao antagonist α2-adrenergičkog receptora.[5][6]

Indikacije[uredi | uredi kod]

Izvori[uredi | uredi kod]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. 
  4. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.  edit
  5. Millan MJ, Cussac D, Milligan G, et al. (June 2001). „Antiparkinsonian agent piribedil displays antagonist properties at native, rat, and cloned, human alpha(2)-adrenoceptors: cellular and functional characterization”. The Journal of Pharmacology and Experimental Therapeutics 297 (3): 876–87. PMID 11356907. 
  6. Gobert A, Di Cara B, Cistarelli L, Millan MJ (April 2003). „Piribedil enhances frontocortical and hippocampal release of acetylcholine in freely moving rats by blockade of alpha 2A-adrenoceptors: a dialysis comparison to talipexole and quinelorane in the absence of acetylcholinesterase inhibitors”. The Journal of Pharmacology and Experimental Therapeutics 305 (1): 338–46. DOI:10.1124/jpet.102.046383. PMID 12649387. 

Spoljašnje veze[uredi | uredi kod]

Vidi još[uredi | uredi kod]


<!Antiparkinson>

Star of life.svg Molimo Vas, obratite pažnju na važno upozorenje u vezi tema o zdravlju (medicini).